Learn About Lafora Disease

What is the definition of Lafora Disease?
Lafora disease is an inherited, severe form of progressive myoclonus epilepsy. The condition most commonly begins with epileptic seizures in late childhood or adolescence. Other signs and symptoms include difficulty walking, muscle spasms (myoclonus) and dementia. Affected people also experience rapid cognitive deterioration that begins around the same time as the seizures. Most cases are caused by changes in either the EPM2A gene or the NHLRC1 gene and are inherited in an autosomal recessive manner.
What are the alternative names for Lafora Disease?
  • Lafora disease
  • EPM2
  • Epilepsy progressive myoclonic 2
  • Lafora body disorder
  • MELF
  • Myoclonic epilepsy of Lafora
Who are the top Lafora Disease Local Doctors?
3650 Nw 82nd Ave, Suite 203, 
Doral, FL 
 (1.7 mi)
Languages Spoken:
English, Spanish
Accepting New Patients

Ariol Labrada is a Neurologist in Doral, Florida. Dr. Labrada and is rated as an Experienced provider by MediFind in the treatment of Lafora Disease. His top areas of expertise are Stroke, Epilepsy with Myoclonic-Atonic Seizures, Myoclonic Epilepsy, and West Syndrome. Dr. Labrada is currently accepting new patients.

5959 Nw 7th St, 
Miami, FL 
 (2.2 mi)
Languages Spoken:
English, Spanish
Accepting New Patients
Offers Telehealth

Aliuska Alvarez is a Neurologist in Miami, Florida. Dr. Alvarez and is rated as an Experienced provider by MediFind in the treatment of Lafora Disease. Her top areas of expertise are Cerebellar Degeneration, Epilepsy, Memory Loss, and Alzheimer's Disease. Dr. Alvarez is currently accepting new patients.

 
 
 
 
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Family Medicine | General Practice
Family Medicine | General Practice
4100 Nw 9th St, Suite 101, 
Miami, FL 
 (3.2 mi)
Languages Spoken:
English, Spanish
Accepting New Patients

Onel Corrales is a Family Medicine specialist and a General Practice provider in Miami, Florida. Dr. Corrales and is rated as an Experienced provider by MediFind in the treatment of Lafora Disease. His top areas of expertise are Fecal Impaction, Primary Orthostatic Tremor, Apraxia, Gastrostomy, and Hip Replacement. Dr. Corrales is currently accepting new patients.

What are the latest Lafora Disease Clinical Trials?
CureDRPLA Global Patient Registry for Individuals With Dentatorubral-pallidoluysian Atrophy (DRPLA)

Summary: The objective of the CureDRPLA Global Patient Registry is to establish a longitudinal database of patient-reported data on individuals affected with Dentatorubral-pallidoluysian atrophy (DRPLA) from anywhere in the world. The CureDRPLA Global Patient Registry will address patient needs by: * Expanding patient engagement by documenting quality of life outcomes. * Providing anonymized data to the DR...

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A Phase 1/2 Open Label Study to Evaluate the Safety and Efficacy of Intrathecally Administered ION283 in Patients With Lafora Disease

Summary: This study will test the safety and efficacy of multiple doses of ION283 administered as intrathecal (IT) injections by lumbar puncture (LP). All subjects will receive ION283. The dose level of 15 mg will be studied in all subjects.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center