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Learn About Landau-Kleffner Syndrome

What is the definition of Landau-Kleffner Syndrome?
Landau-Kleffner syndrome (LKS) is a rare neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and recurrent seizures (epilepsy). Males are more often affected by LKS than females. In about 20% of people with LKS, genetic changes (changes) in the GRIN2A gene have been identified. The syndrome is inherited in an autosomal dominant manner. In other cases, the syndrome may be caused by changes to other unidentified genes. LKS is diagnosed when a doctor sees clinical features that are consistent with the syndrome such as a loss of speech and an electroencephalogram (EEG) that shows specific kinds of seizure activity. Genetic testing can be used to confirm if there is a genetic change in GRIN2A, but this testing is not done routinely.
What are the alternative names for Landau-Kleffner Syndrome?
  • Landau-Kleffner syndrome
  • Acquired aphasia with convulsive disorder
  • Acquired epileptic aphasia
  • Acquired epileptiform aphasia
  • LKS
Who are the top Landau-Kleffner Syndrome Local Doctors?
Internal Medicine
Internal Medicine
3738 Davis Stuart Rd, 
Lewisburg, WV 
 20.6 mi

Dorris Ragsdale is an Internal Medicine provider in Lewisburg, West Virginia. Dr. Ragsdale and is rated as an Experienced provider by MediFind in the treatment of Landau-Kleffner Syndrome. Her top areas of expertise are Anemia, Low Potassium Level, Gitelman Syndrome, and Muscle Atrophy.

Camc Greenbrier Valley Medical Center Inc

1322 Maplewood Ave, Suite A, 
Ronceverte, WV 
 21.2 mi
Accepting New Patients
Offers Telehealth

Constance Anderson is a Family Medicine provider in Ronceverte, West Virginia. Dr. Anderson and is rated as an Experienced provider by MediFind in the treatment of Landau-Kleffner Syndrome. Her top areas of expertise are Gitelman Syndrome, Low Potassium Level, Lung Metastases, and Vascular Dementia. Dr. Anderson is currently accepting new patients.

 
 
 
 
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Family Medicine
Family Medicine
350 Fairview Heights Rd, 
Summersville, WV 
 22.6 mi
Accepting New Patients

Margaret Wantz is a Family Medicine provider in Summersville, West Virginia. Dr. Wantz and is rated as an Experienced provider by MediFind in the treatment of Landau-Kleffner Syndrome. Her top areas of expertise are Childhood Volvulus, Cellulitis, Hospital-Acquired Pneumonia, and Atypical Pneumonia. Dr. Wantz is currently accepting new patients.

What are the latest Landau-Kleffner Syndrome Clinical Trials?
Music and Cognitive Deficits in Self-Limited Epilepsy with Centrotemporal Spikes

Summary: Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. SeLECTS is associated in 15 to 30% of patients with specific cognitive deficits, including in particular disorders in language, visuo-spatial memory, declarative memory, and attention. SeLECTS has the potential to evolve into Landau-Kleffner syndrome, th...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center