Learn About Langerhans Cell Histiocytosis
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. Many researchers now consider Langerhans cell histiocytosis to be a form of cancer, but this classification remains controversial.
Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. Somatic gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes are not inherited.
Langerhans cell histiocytosis is a rare disorder. Its prevalence is estimated at 1 to 2 in 100,000 people.
Langerhans cell histiocytosis is usually not inherited and typically occurs in people with no history of the disorder in their family.
Vince Lombardi Cancer Clinic
Syed Abutalib is a Hematologist in Milwaukee, Wisconsin. Dr. Abutalib is rated as a Distinguished provider by MediFind in the treatment of Langerhans Cell Histiocytosis. His top areas of expertise are Langerhans Cell Histiocytosis, Relapsed Refractory Multiple Myeloma (RRMM), Multiple Myeloma, Bone Marrow Aspiration, and Bone Marrow Transplant.
MN - Cancer Hematology
Jithma Abeykoon is a Hematologist in Rochester, Minnesota. Dr. Abeykoon is rated as an Elite provider by MediFind in the treatment of Langerhans Cell Histiocytosis. His top areas of expertise are Histiocytosis, Waldenstrom Macroglobulinemia, Reticulohistiocytoma, Tissue Biopsy, and Bone Marrow Transplant.
Vince Lombardi Cancer Clinic
Syed Haider is a Hematologist in Milwaukee, Wisconsin. Dr. Haider is rated as an Advanced provider by MediFind in the treatment of Langerhans Cell Histiocytosis. His top areas of expertise are Small Lymphocytic Lymphoma (SLL), Multiple Myeloma, Chronic Myelogenous Leukemia (CML), Bone Marrow Aspiration, and Bone Marrow Transplant.
Summary: This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a type of disease that occurs when the body makes too ma...
Summary: The purpose of this study is to determine the uptake of the imaging agent \[68Ga\]-pentixafor with PET/CT scans in people with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and non-Hodgkin lymphoma (NHL), or you have histiocytic neoplasms (Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD) and/or Rosai-Dorfman disease (RDD).
Published Date: October 01, 2017
Published By: National Institutes of Health