Langerhans Cell HistiocytosisSymptoms, Doctors, Treatments, Advances & More
Learn About Langerhans Cell Histiocytosis
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. Many researchers now consider Langerhans cell histiocytosis to be a form of cancer, but this classification remains controversial.
Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. Somatic gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes are not inherited.
Langerhans cell histiocytosis is a rare disorder. Its prevalence is estimated at 1 to 2 in 100,000 people.
Langerhans cell histiocytosis is usually not inherited and typically occurs in people with no history of the disorder in their family.
Vince Lombardi Cancer Clinic
Syed Abutalib is a Hematologist practicing medicine in Milwaukee, Wisconsin. Dr. Abutalib is rated as a Distinguished provider by MediFind in the treatment of Langerhans Cell Histiocytosis. He is also highly rated in 19 other conditions, according to our data. His clinical expertise encompasses Langerhans Cell Histiocytosis, Relapsed Refractory Multiple Myeloma (RRMM), Multiple Myeloma, Bone Marrow Aspiration, and Bone Marrow Transplant. Dr. Abutalib is board certified in American Board Of Internal Medicine, Medical Oncology.
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Carl Allen is a Hematologist and an Oncologist practicing medicine in Houston, Texas. Dr. Allen is rated as an Elite provider by MediFind in the treatment of Langerhans Cell Histiocytosis. He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Langerhans Cell Histiocytosis, Reticulohistiocytoma, Histiocytosis, Hemophagocytic Lymphohistiocytosis, and Bone Marrow Transplant.
MN - Cancer Hematology
Jithma Abeykoon is a Hematologist practicing medicine in Rochester, Minnesota. Dr. Abeykoon is rated as an Elite provider by MediFind in the treatment of Langerhans Cell Histiocytosis. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Waldenstrom Macroglobulinemia, Reticulohistiocytoma, Histiocytosis, Tissue Biopsy, and Bone Marrow Transplant.
Summary: This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a type of disease that occurs when the body makes too ma...
Summary: The purpose of the study is to describe the burden of chronic health conditions, psychological dysfunction, chronic pain, healthcare utilization, worse health-related quality of life, overall mortality, and cause-specific mortality among individuals with histiocytic disorders
Published Date: October 01, 2017
Published By: National Institutes of Health