PROspective Phase II Trial of Pre-operative Hypofractionated protoN Therapy for Extremity and Truncal Soft Tissue sarcOma

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study is being done to examine whether proton therapy for certain kinds of sarcomas (extremity and trunk soft tissue) is safe and effective. As part of the study, patients will have five fractions of proton therapy before the participants have surgery for the sarcoma. The study will measure wound complications and functional outcomes / quality of life after the procedures. Patients will be asked to complete questionnaires about the treatment and quality of life from the time of enrollment until about two years after surgery. Otherwise, the participants will have standard of care follow ups with the treatment team.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patients (≥18 years of age)

• Patients with primary or locally recurrent extremity or truncal soft tissue sarcoma

• WHO/ECOG status ≤2

Locations
United States
Washington, D.c.
Sibley Memorial Hospital
RECRUITING
Washington D.c.
Contact Information
Primary
Curtiland Deville, MD
cdeville@jhmi.edu
202-537-4788
Backup
Ryan Manuel
rmanuel5@jhmi.edu
Time Frame
Start Date: 2024-04-18
Estimated Completion Date: 2032-12
Participants
Target number of participants: 40
Treatments
Experimental: Pre-operative hypofractionated proton therapy
Patients will have 5 fractions of proton therapy prior to surgical resection of their sarcoma.
Related Therapeutic Areas
Sponsors
Collaborators: Robert L. Sloan Fund for Cancer Research
Leads: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

This content was sourced from clinicaltrials.gov