Deep Learning for Histopathological Classification and Prognostication of Gynaecologic Smooth Muscle Tumours

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Smooth muscle tumors of the uterus that do not fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas) are called STUMP (smooth muscle tumor of uncertain malignant potential). A potential solution to this problem could be the application of predictive models using artificial intelligence (AI) to aid in the histopathological classification and prognosis of gynecological smooth muscle tumors. Deep learning using convolutional neural networks represents a specific class of machine learning, in which predictive models are trained by considering small groups of pixels in digital images and iteratively identifying salient features. In this study, we aim to develop deep learning models capable of accurately subclassifying and predicting the prognosis of gynecological smooth muscle tumors, based on histopathological features of hematoxylin and eosin (H\&E) slides. The aim is to develop a diagnostic and prognostic algorithm to help pathologists better classify and diagnose uterine smooth muscle tumors and predict their clinical course.

Eligibility
Participation Requirements
Sex: Female
Healthy Volunteers: f
View:

• Patients with a diagnosis of uterine smooth muscle tumors (leiomyomas, smooth muscle tumors of uncertain malignancy and leiomyosarcomas), registered in the RRePS database and/or treated at Institut Bergonié or one of the participating centers.

• Histopathological material available (kerosene blocks and/or slides).

Locations
Other Locations
France
Institut Bergonie
RECRUITING
Bordeaux
Contact Information
Primary
Sabrina CROCE
s.croce@bordeaux.unicancer.fr
+33556333333
Time Frame
Start Date: 2023-12-01
Estimated Completion Date: 2024-12
Participants
Target number of participants: 392
Treatments
STUMP cohort
Smooth muscle tumors of the uterus that do not fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas) : smooth muscle tumor of uncertain malignant potential
Leiomyoma-leiomyosarcoma
Smooth muscle tumors of the uterus that do fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas)
Sponsors
Leads: Institut Bergonié

This content was sourced from clinicaltrials.gov