• Diagnosis of acute myeloid leukemia (AML) according to the 2008 criteria of the World Health Organization (WHO).

• Patients completed induction and consolidation chemotherapy and have achieved complete remission (CR) by bone marrow biopsy criteria but with persistent MRD (defined by upregulated WT1 level and less than 5% of blast cells in bone marrow biopsy) and are not eligible for stem cell transplant

• Patients have MRD molecular relapse (defined by upregulated WT1 level and less than 5% of blast cells in bone marrow biopsy) after achieved CR following induction and consolidation chemotherapy.

• Patients with molecular relapse (define by upregulated WT1 level and less than 5% of blast cells in bone marrow biopsy) after allogeneic stem cell transplant

• Leukemic cells express at least one of the following antigens: WT1, hTERT or survivin detected by qRT-PCR and/or flow cytometry or immunohistochemistry

• Karnofsky PS ≥60% or ECOG PS≤2.

• Patients must have organ and marrow function as defined below:

‣ leukocytes \>=3,000/mcL

⁃ absolute neutrophil count \>=1,500/mcL

⁃ platelets \>=100,000/mcL

⁃ hemoglobin \>=9.0 g/dL

⁃ total bilirubin within normal institutional limits except in patients with Gilberts Syndrome who must have a total bilirubin \< 3.0 mg/dL

⁃ AST(SGOT)/ALT(SGPT) Serum ALT/AST \< 2.5X ULN

⁃ creatinine clearance Calculated creatinine clearance (CrCl) \>=50 mL/min/1.73 m\^2 for patients with creatinine levels above institutional normal (by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation)

⁃ Adequate cardiac function: LVEF ≥50% by MUGA

• Ability of subject to understand and the willingness to sign a written informed consent document.