Predictive Value of Myelodysplastic Syndrome Stem Cells Determined by Multiparameter Flow Cytometry in Patients Receiving Allotransplantation: a Multi-center, Prospective Clinical Study

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Presently, multiparameter flow cytometry (MFC) and polymerase chain reaction (PCR) have been used for disease load, including measurable residual disease (MRD), monitoring in patients with myelodysplastic syndrome (MDS). MFC is the most commonly method for disease load evaluation. In patients with acute myeloid leukemia, leukemia stem cells (LSCs) determined using MFC for leukemia load and MRD detection is superior to traditional MFC method. In the investigators previous single center study, the investigators demonstrated that detection of disease load, including MRD, by MFC in patients with MDS-EB is superior to predict outcomes after allogeneic stem cell transplantation. Here, the investigators will perform a multi-center, prospective clinical trial to investigate the predictive values of MDS-SC in patients with MDS-EB who received allografting.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 70
Healthy Volunteers: f
View:

• Patients with Myelodysplastic syndromes;

• Between 15 and 70 years old;

• Subjects are able to provide written informed consent.

Locations
Other Locations
China
Chinese PLA General Hospital
RECRUITING
Beijing
Peking University People's Hospital
RECRUITING
Beijing
Wuhan TongJi Hospital
RECRUITING
Wuhan
The First Affiliated Hospital of Zhengzhou University
RECRUITING
Zhengzhou
Contact Information
Primary
chief physician
rmcyj@bjmu.edu.cn
13520536738
Time Frame
Start Date: 2024-12-09
Estimated Completion Date: 2027-12-18
Participants
Target number of participants: 163
Treatments
MDS-EB
Sponsors
Collaborators: The First Affiliated Hospital of Zhengzhou University, Peking University First Hospital, Wuhan TongJi Hospital, Chinese PLA General Hospital
Leads: Peking University People's Hospital

This content was sourced from clinicaltrials.gov