Observational Study on APL-like Subset Within NPM1-mutated Acute Myeloid Leukemia: a Distinct Phenotypic Signature Correlating With Early-onset Vascular Complications. ACTIVATE (APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions)
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with de novo AML, untreated, newly diagnosed, according to WHO/ICC 2022 criteria from January 2015 onwards.
• Presence of NPM1 mutation.
• Availability of immunophenotypic characterization at diagnosis
• Age \>= 18 years
• Signed written informed consent according to ICH/EU/GCP and national local laws (if applicable)
Locations
Other Locations
Italy
SOD Ematologia, Università di Firenze, AOU Careggi
RECRUITING
Florence
Contact Information
Primary
Paola Fazi
p.fazi@gimema.it
0670390528
Backup
Enrico Crea
e.crea@gimema.it
0670390514
Time Frame
Start Date: 2026-07
Estimated Completion Date: 2028-11
Participants
Target number of participants: 220
Treatments
APL-like
NPM1 AML patients identified as APL-like cohort
Non APL-like
NPM1 AML patients identified as no APL-like cohort
Related Therapeutic Areas
Sponsors
Leads: Gruppo Italiano Malattie EMatologiche dell'Adulto