Characterization of T-cell Repertoire in Patients With AML Undergoing HSCT Through Next-Generation Sequencing of T Cell Receptor Alpha (TCRA) and T Cell Receptor Beta (TCRB) Genes
Status: Recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Observational
SUMMARY
This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Diagnosis of AML scheduled to undergo HSCT at University of Southern California (USC)
Locations
United States
California
USC / Norris Comprehensive Cancer Center
RECRUITING
Los Angeles
Contact Information
Primary
Christine Duran
Duran_C@med.usc.edu
323-865-0371
Time Frame
Start Date: 2018-04-12
Estimated Completion Date: 2027-05-15
Participants
Target number of participants: 250
Treatments
Ancillary-correlative (next generation sequencing)
Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for RNA-based next generation sequencing of TCRA and TCRB genes.
Related Therapeutic Areas
Sponsors
Leads: University of Southern California
Collaborators: National Cancer Institute (NCI)