Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Leukoplakia?

Leukoplakia are patches on the tongue, in the mouth, or on the inside of the cheek.

What are the alternative names for Leukoplakia?

Hairy leukoplakia; Smoker's keratosis

What are the causes for Leukoplakia?

Leukoplakia affects the mucous membranes of the mouth. The exact cause is not known. It may be due to irritation such as:

  • Rough teeth
  • Rough places on dentures, fillings, and crowns
  • Smoking or other tobacco use (smoker's keratosis), especially pipes
  • Holding chewing tobacco or snuff in the mouth for a long period of time
  • Drinking a lot of alcohol

The disorder is more common in older adults.

A type of leukoplakia of the mouth, called oral hairy leukoplakia, is caused by the Epstein-Barr virus. It is seen mostly in people with HIV/AIDS. It may be one of the first signs of HIV infection. Oral hairy leukoplakia can also appear in other people whose immune system is not working well, such as after a bone marrow transplant.

What are the symptoms for Leukoplakia?

Patches in the mouth usually develop on the tongue (sides of the tongue with oral hairy leukoplakia) and on the insides of the cheeks.

Leukoplakia patches are:

  • Most often white or gray
  • Uneven in shape
  • Fuzzy (oral hairy leukoplakia)
  • Slightly raised, with a hard surface
  • Unable to be scraped off
  • Painful when the mouth patches come into contact with acidic or spicy food

What are the current treatments for Leukoplakia?

The goal of treatment is to get rid of the leukoplakia patch. Removing the source of irritation may cause the patch to disappear.

  • Treat dental causes such as rough teeth, irregular denture surface, or fillings as soon as possible.
  • Stop smoking or using other tobacco products.
  • Do not drink alcohol.

If removing the source of the irritation does not work, your health care provider may suggest applying medicine to the patch or using surgery to remove it.

For oral hairy leukoplakia, taking antiviral medicine usually causes the patch to disappear. Your provider may also suggest applying medicine to the patch.

What is the outlook (prognosis) for Leukoplakia?

Leukoplakia is usually harmless. Patches in the mouth often clear up in a few weeks or months after the source of irritation is removed.

In some cases, the patches may be an early sign of cancer.

When should I contact a medical professional for Leukoplakia?

Call for an appointment with your provider if you have any patches that look like leukoplakia or hairy leukoplakia.

How do I prevent Leukoplakia?

Stop smoking or using other tobacco products. Do not drink alcohol, or limit the number of drinks you have. Have rough teeth treated and dental appliances repaired right away.


Holmstrup P, Dabelsteen E. Oral leukoplakia-to treat or not to treat. Oral Dis. 2016;22(6):494-497. PMID: 26785709

James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Disorders of the mucous membranes In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin. 13th ed. Philadelphia, PA: Elsevier; 2020:chap 34.

Sciubba JJ. Oral mucosal lesions. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 89.

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Latest Research

Latest Advance
  • Condition: Oral Leukoplakia
  • Journal: La Clinica terapeutica
  • Treatment Used: CO2 Laser Ablation
  • Number of Patients: 30
  • Published —
This study tested the safety and efficacy of using a CO2 laser ablation therapy to treat patients with oral leukoplakia.
Latest Advance
  • Condition: Oral Leukoplakia (OL)
  • Journal: Photodiagnosis and photodynamic therapy
  • Treatment Used: Photodynamic Therapy and Fractional CO2 Laser
  • Number of Patients: 3
  • Published —
This study presented cases of oral leukoplakia (white mucosa; OL) successfully treated by ALA photodynamic therapy (PDT) following pretreatment with CO2 laser.

Clinical Trials

Clinical Trial
Dietary Supplement
  • Status: Recruiting
  • Study Type: Dietary Supplement
  • Participants: 66
  • Start Date: February 1, 2020
Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study
Clinical Trial
  • Status: Recruiting
  • Participants: 500
  • Start Date: December 1, 2019
Prospective Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore