Learn About Leydig Cell Testicular Tumor

What is the definition of Leydig Cell Testicular Tumor?

A Leydig cell tumor is a tumor of the testicle. It develops from Leydig cells. These are the cells in the testicles that release the male hormone, testosterone.

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What are the alternative names for Leydig Cell Testicular Tumor?

Tumor - Leydig cell; Testicular tumor - Leydig

What are the causes of Leydig Cell Testicular Tumor?

The cause of this tumor is unknown. There are no known risk factors for this tumor. Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes.

Leydig cell tumors make up a very small number of all testicular tumors. They are most often found in men between 30 and 60 years of age. This tumor is not common in children before puberty, but it may cause early puberty.

What are the symptoms of Leydig Cell Testicular Tumor?

There may be no symptoms.

When symptoms do occur, they can include:

  • Discomfort or pain in the testicle
  • Enlargement of a testicle or change in the way it feels
  • Excess growth of breast tissue (gynecomastia) -- however, this can occur normally in adolescent boys who do not have testicular cancer
  • Heaviness in the scrotum
  • Lump or swelling in either testicle
  • Pain in the lower abdomen or back
  • Not able to father children (infertility)

Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain may also occur if the cancer has spread.

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What are the current treatments for Leydig Cell Testicular Tumor?

Treatment of a Leydig cell tumor depends on its stage.

  • Stage I cancer has not spread beyond the testicle.
  • Stage II cancer has spread to lymph nodes in the abdomen.
  • Stage III cancer has spread beyond the lymph nodes (possibly as far as the liver, lungs, or brain).

Surgery is done to remove the testicle (orchiectomy). Nearby lymph nodes may also be removed (lymphadenectomy).

Chemotherapy may be used to treat this tumor. As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers.

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What are the support groups for Leydig Cell Testicular Tumor?

Joining a support group where members share common experiences and problems can often help ease the stress of illness.

What is the outlook (prognosis) for Leydig Cell Testicular Tumor?

Testicular cancer is one of the most treatable and curable cancers. Outlook is worse if the tumor is not found early.

What are the possible complications of Leydig Cell Testicular Tumor?

The cancer may spread to other parts of the body. The most common sites include the:

  • Abdomen
  • Lungs
  • Retroperitoneal area (the area near the kidneys behind the other organs in the belly area)
  • Spine

Complications of surgery can include:

  • Bleeding and infection
  • Infertility (if both testicles are removed)

If you are of childbearing age, ask your provider about methods to save your sperm for use at a later date.

When should I contact a medical professional for Leydig Cell Testicular Tumor?

Call your provider if you have symptoms of testicular cancer.

How do I prevent Leydig Cell Testicular Tumor?

Performing testicular self-examination (TSE) each month may help detect testicular cancer at an early stage, before it spreads. Finding testicular cancer early is important for successful treatment and survival.

Male reproductive anatomy
What are the latest Leydig Cell Testicular Tumor Clinical Trials?
A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex Cord-Stromal Tumors of the Ovary
Summary: This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or has returned (recurrent). Drugs used in chemotherapy work in diffe...
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International Pleuropulmonary Blastoma Registry for PPB, DICER1 and Associated Conditions
Summary: Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the treating institution. This study builds off of the 2009 study and will also seek to enroll individuals with ...
What are the Latest Advances for Leydig Cell Testicular Tumor?
Ovarian Leydig Cell Tumor: Cause of Virilization in a Postmenopausal Woman.
Summary: Ovarian Leydig Cell Tumor: Cause of Virilization in a Postmenopausal Woman.
Immunohistochemical Characterization of 120 Testicular Sex Cord-Stromal Tumors With an Emphasis on the Diagnostic Utility of SOX9, FOXL2, and SF-1.
Summary: Immunohistochemical Characterization of 120 Testicular Sex Cord-Stromal Tumors With an Emphasis on the Diagnostic Utility of SOX9, FOXL2, and SF-1.
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Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Summary: Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome: A case report and literature review.
Who are the sources who wrote this article ?

Published Date: April 29, 2022
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Friedlander TW, Small E. Testicular cancer. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 83.

National Cancer Institute website. Testicular cancer treatment (PDQ) – health professional version. www.cancer.gov/types/testicular/hp/testicular-treatment-pdq. Updated February 11, 2022. Accessed June 24, 2022.

Stephenson AJ, Gilligan TD. Neoplasms of the testis. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 76.