Male Lichen Sclerosus - Risk Factors, Treatment, and Impact on Quality of Life
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
This observational study aims to evaluate routine treatment outcomes in men with lichen sclerosus (LS), including a long-term follow-up to assess disease progression and histopathological changes. The study also investigates potential risk factors for LS and the disease's impact on quality of life and sexual health.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: t
View:
• Biologically male
• ≥18 years old
• Referred to the dermatology department or the urology department in Västerbotten and diagnosed with LS.
• Must be able to read and write Swedish to fill in questionnaire and informed consent.
• Biologically male
• ≥18 years old
• Phimosis without LS, treated with circumcision at the urology department in Västerbotten
• Must be able to read and write Swedish to fill in questionnaire and informed consent.
• Biologically male with male genitalia
• ≥18 years old
• No genital symptoms
• Must be able to read and write Swedish to fill in questionnaire and informed consent.
Locations
Other Locations
Sweden
Umeå University Hospital
RECRUITING
Umeå
Contact Information
Primary
Maja af Klinteberg, MD, PhD
maja.af.klinteberg@umu.se
0046-90785 00 00
Backup
Amir Sherif, MD, PhD
amir.sherif@umu.se
Time Frame
Start Date:2025-10-06
Estimated Completion Date:2038-10
Participants
Target number of participants:300
Treatments
LS Urology
Male patients (≥18 years), undergoing circumcision due to phimosis at the Department of Urology. Diagnosis of lichen sclerosus (LS) confirmed by histopathological examination of the foreskin. Participants will complete questionnaires and provide biological samples (e.g., skin, urine, and fecal samples) for exploratory analyses. Follow-up will be conducted to assess long-term treatment outcomes.
LS dermatology
Male patients (≥18 years), diagnosed with LS in outpatient care at the Department of Dermatology. Participants will complete questionnaires and be followed over time to evaluate treatment and quality of life.
Controls - Urology
Male patients (≥18 years), undergoing circumcision at the Department of Urology, with no histopathological evidence of LS. These participants will provide biological samples at baseline and serve as urology-based controls for comparison with LS patients.
Controls - General Population
Male participants (≥18 years) without any known genital symptoms or history of LS, recruited from the general population. They will complete the same questionnaire as other study groups but will not be sampled or followed longitudinally.