MediFind
Condition

Lichen Sclerosus

Condition 101

What is the definition of Lichen Sclerosus?

Lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. In men, it typically affects the tip of the penis. It can occur at any age but is usually seen in women over age 50. Some people have no ...

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What are the alternative names for Lichen Sclerosus?

  • Lichen sclerosis
  • Lichen sclerosis et atrophicus
  • Lichen sclerosus et atrophicus

What are the causes for Lichen Sclerosus?

The underlying cause of lichen sclerosus is not fully understood. The condition may be due to genetic, hormonal, irritant and/or infectious factors (or a combination of these factors). It is believed to relate to an autoimmune process, in which antibodies mistakenly attack a component of the skin. Other autoimmune conditions are reported to occur more frequently than expected in people with lichen sclerosus. In some cases, lichen sclerosus appears on skin that has been damaged or scarred from previous injury or trauma.

What are the symptoms for Lichen Sclerosus?

The symptoms are the same in children and adults. Early in the disease, small, subtle white spots appear. These areas are usually slightly shiny and smooth. As time goes on, the spots develop into bigger patches, and the skin surface becomes thinned and crinkled. As a result, the skin tears easily, and bright red or purple discoloration from bleeding inside the skin is common. 

Symptoms vary depending on the area affected. Patients experience different degrees of discomfort. When lichen sclerosus occurs on parts of the body other than the genital area, most often there are no symptoms, other than itching. If the disease is severe, bleeding, tearing, and blistering caused by rubbing or bumping the skin can cause pain.

What are the current treatments for Lichen Sclerosus?

Strong topical steroid creams or ointments reportedly are very helpful for lichen sclerosus, especially when it affects the genital areas. However, the response to this treatment varies. While itching may be relieved within days, it can take weeks or months for the skin's appearance to return to normal.

Other treatments that may be used instead of steroid creams, or in combination with steroid creams, include calcipotriol cream, topical and systemic retinoids (acitretin), and/or systemic steroids.

If the vaginal opening has narrowed, dilators may be needed. In rare cases, surgery is necessary to allow for sexual intercourse. The condition sometimes causes the vaginal opening to narrow or close again after surgery is initially successful.

Additional information about treatment of lichen sclerosus can be viewed on Medscape's Web site.

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Andreas R. Gunthert
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Simone Cazzaniga
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Latest Research

Latest Advance
Study
  • Condition: Localized Bullous Morphea
  • Journal: Dermatology online journal
  • Treatment Used: Topical Betamethasone and Silicone Gel Ointment
  • Number of Patients: 1
  • Published —
This case report discusses a 54-year-old woman with bullous morphea (skin blisters) and some features of lichen sclerosus treated with topical betamethasone and silicone gel ointment.
Latest Advance
Study
  • Condition: Lichen Sclerosus
  • Journal: F1000Research
  • Treatment Used: Circumcision and topical steroids
  • Number of Patients: 0
  • Published —
The study researched the advances of treatment and management for Lichen Sclerosus.
Latest Advance
Study
  • Condition: Balanitis Xerotica Obliterans (BXO)
  • Journal: European journal of pediatrics
  • Treatment Used: Medication and Surgery
  • Number of Patients: 0
  • Published —
This article provides an update for balanitis xerotica obliterans (BXO), a severe, chronic, dermatosis characterized by inflammatory, sclerotic, pruritic lesions that affects the foreskin and glans in boys, and its treatments.
Latest Advance
Study
  • Condition: Selected Penile Urethral Strictures
  • Journal: Asian journal of andrology
  • Treatment Used: Single-Stage Tubular Urethral Reconstruction Using Oral Grafts
  • Number of Patients: 0
  • Published —
This study identified penile urethral stricture factors which indicate suitability for a two-in-one stage approach.

Clinical Trials

Clinical Trial
Device
  • Status: Recruiting
  • Study Type: Device
  • Participants: 60
  • Start Date: January 1, 2020
Effect of Treatment With the Ablative Fractional Carbodioxide Laser in Vulvar Lichen Sclerosis
Clinical Trial
Device
  • Status: Recruiting
  • Study Type: Device
  • Participants: 30
  • Start Date: January 1, 2020
Effectiveness of Ablative Fractional 2940 nm Laser Treatment for Vulvar Lichen Sclerosus