Liddle syndrome is an inherited form of high blood pressure (hypertension). This condition is characterized by severe hypertension that begins unusually early in life, often in childhood, although some affected individuals are not diagnosed until adulthood. Some people with Liddle syndrome have no additional signs or symptoms, especially in childhood. Over time, however, untreated hypertension can lead to heart disease or stroke, which may be fatal.
Liddle syndrome is caused by mutations in the SCNN1B or SCNN1G gene. Each of these genes provides instructions for making a piece (subunit) of a protein complex called the epithelial sodium channel (ENaC). These channels are found at the surface of certain cells called epithelial cells in many tissues of the body, including the kidneys, where the channels transport sodium into cells.
Liddle syndrome is a rare condition, although its prevalence is unknown. The condition has been found in populations worldwide.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Kun-qi Yang practices in Beijing, China. Yang is rated as an Elite expert by MediFind in the treatment of Liddle Syndrome. They are also highly rated in 7 other conditions, according to our data. Their top areas of expertise are Liddle Syndrome, Low Potassium Level, Apparent Mineralocorticoid Excess, Takayasu Arteritis, and Angioplasty.
Peng Fan practices in Beijing, China. Fan is rated as an Elite expert by MediFind in the treatment of Liddle Syndrome. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Liddle Syndrome, Low Potassium Level, Takayasu Arteritis, Pacemaker Implantation, and Heart Transplant.
Toshiaki Makino practices in Nagoya, Japan. Makino is rated as an Elite expert by MediFind in the treatment of Liddle Syndrome. He is also highly rated in 2 other conditions, according to our data. His top areas of expertise are Liddle Syndrome, Low Potassium Level, Tonsillitis, and Rhabdomyolysis.
Published Date: March 01, 2013Published By: National Institutes of Health