Condition 101 About Liposarcoma

What is the definition of Liposarcoma?

Liposarcoma is a tumor that arises from fat tissue. This tumor often occurs in the thigh, legs, behind the knee, or in the abdomen, but it can be found in other parts of the body, in the retroperitoneum; and, less often, in the head and neck area. Their primary occurrence in the skin is rare. Because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. The World Health Organization classification of soft tissue tumors recognizes 5 types of liposarcomas: Well differentiated, which includes the adipocytic, sclerosing, and inflammatory subtypes; dedifferentiated; myxoid; round cell; and pleomorphic. Most patients with liposarcoma have no symptoms until the tumor is large and invades the neighboring organs or tissues, causing tenderness, pain, or functional problems. Although surgical removal of the tumor is the curative treatment, some patients may benefit from chemotherapy and radiation.

What are the current treatments for Liposarcoma?

The treatment for liposarcoma depends on the type, size, and location of the tumor.  Surgery to remove the tumor is often the first treatment.  When the tumor is in the abdomen, it may be difficult to remove completely, especially if the tumor is growing near important organs that cannot be removed.  If the entire tumor cannot be removed during surgery, radiation therapy may be used after surgery to kill any cancer cells that remain to reduce the chance of the tumor coming back (a recurrence).   Chemotherapy is another treatment that can kill remaining cancer cells following surgery, though it is not usually used to treat low-grade sarcomas. 

Sometimes radiation therapy or chemotherapy may be done prior to surgery to shrink the tumor; this may increase the chance of removing the whole tumor during surgery while limiting the impact to other organs.  

Latest Advances On Liposarcoma

  • Condition: Hourglass Transmural Lipoma
  • Journal: Kyobu geka. The Japanese journal of thoracic surgery
  • Treatment Used: Video-Assisted Thoracic Surgery
  • Number of Patients: 1
  • Published —
This case report describes a patient with an hourglass transmural lipoma that was treated using a video-assisted thoracic surgery.
  • Condition: Polymyalgic complaint
  • Journal: Deutsche medizinische Wochenschrift (1946)
  • Treatment Used: Complete Tumor Resection
  • Number of Patients: 1
  • Published —
This case report describes a 61-year-old caucasian male diagnosed with polymyalgia rheumatica treated with 20?mg prednisone/day, after which MRI revealed a retroperitoneal liposarcoma that was treated with complete tumor resection.

Clinical Trials For Liposarcoma

Clinical Trial
  • Status: Not yet recruiting
  • Intervention Type: Radiation, Procedure
  • Participants: 100
  • Start Date: January 2021
International Prospective Registry on Local Treatment Approaches in Myxoid Liposarcomas
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 2
  • Intervention Type: Biological
  • Participants: 75
  • Start Date: December 3, 2020
A Phase II Multi-Arm Study to Test the Efficacy of Oleclumab and Durvalumab in Multiple Sarcoma Subtypes