Single-cell Landscape of Immunological Responses in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This study aimed to profile the peripheral blood immune cells of patients with HBV related acute-on-chronic liver failure using single-cell RNA sequencing to reveal the immunopathological mechanisms of HBV related acute-on-chronic liver failure.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Acute liver failure is a well-defned medical emergency which is defned as a severe liver injury, leading to coagulation abnormality usually with an INR ≥ 1.5, and any degree of mental alteration (encephalopathy) in a patient without pre-existing liver disease and with an illness of up to 4 weeks duration
Locations
Other Locations
China
Qilu Hospital of Shandong University
RECRUITING
Jinan
Contact Information
Primary
Yu-Chen Fan
fanyuchen@sdu.edu.cn
0086+053182169593
Time Frame
Start Date: 2023-11-01
Estimated Completion Date: 2025-05
Participants
Target number of participants: 21
Treatments
Chronic Hepatitis B
HBV related liver cirrhosis
HBV related acute-on-chronic hepatic dysfunction
HBV related acute-on-chronic liver failure
Related Therapeutic Areas
Sponsors
Leads: Qilu Hospital of Shandong University