Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time. Researchers will enroll people with Long COVID as well as people who have fully recovered after COVID-19 infection. Participants will provide health information and biological samples, such as blood, saliva, stool, and, for some participants, tissue biopsies. These samples will be used to study the biological processes involved in Long COVID and to support the development of new diagnostic tests that may improve future research, clinical trials, and patient care.
• Willing and able to provide written informed consent, and
• Age \>/= 18 years, and
• Either:
⁃ History of a SARS-CoV-2 infection resulting in Long COVID symptoms, confirmed by the investigator, or
⁃ Exposure to SARS-CoV-2 without establishment of Long COVID.
• Enrolled or willing to enroll and complete at least 1 visit in the UCSF Long-term Impact of Infection with Novel Coronavirus (LIINC).
• Enrolled or willing to be referred for a gut biopsy procedure under related IRB-approved protocols.