Does Exercise Training Mostly Unmask Congenital Long QT Syndrome or Simply Reveals a Novel Form of Acquired Long QT Syndrome in Genetically Predisposed Youngsters Practicing Sports?

Status: Completed
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

QT interval prolongation occurs in athletes and causes concerns, as it may indicate the life-threatening long QT syndrome (LQTS). Clinical and genetic testing identify those clearly affected by LQTS but in many no disease-causing mutations are found and diagnosis remains uncertain while they are barred from competitive sports. The investigators hypothesize that several cases represent an acquired form of LQTS, akin to drug-induced LQTS, caused by exercise training acting as a trigger or second hit on a genetic predisposition. The investigators will use next generation sequencing to screen major and minor LQTS genes plus common and rare variants modulating the QT interval in athletes with a QTc\>450ms (cases) and in those with a QTc\<430ms (controls). Thus, the investigators will quantify the presence of LQTS in athletes and will also focus on those who normalize their QTc after detraining, as this points to activation of stretch-receptors. The investigators will clarify QT prolongation in athletes and contribute to correct diagnosis.

Eligibility
Participation Requirements
Sex: All
View:

• Athletes

• QTc interval \> 450 msec (cases) or \< 430 msec (controls)

Locations
Other Locations
Italy
Istituto Auxologico Italiano - Center for Cardiac Arrhythmias of Genetic Origin
Milan
Time Frame
Start Date: 2018-12-05
Completion Date: 2023-04-04
Participants
Target number of participants: 869
Treatments
Cases
Athletes with QT interval prolongation
Controls
Athletes without QT interval prolongation
Related Therapeutic Areas
Sponsors
Leads: Istituto Auxologico Italiano

This content was sourced from clinicaltrials.gov