Imaging Biomarkers for Immune Checkpoint Inhibitor Treatment in Patients With Non-small Cell Lung Cancer: Prospective Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

1. Hypothesis : imaging biomarkers of tumor measured by F-18 fluorodeoxyglucose (FDG) positron emission tomography(PET)/computed tomography(CT) is correlated with immune checkpoint inhibitor (ICI) treatment response and patient prognosis. 2. Purpose: To evaluate the association between metabolic imaging parameters measured by F-18 FDG PET/CT and clinical outcomes in patients with non-small cell lung cancer treated with ICIs. 3. Study subject: patients with non-small cell lung cancer who will be treated with ICIs. 4. Study design: prospective observational study 5. Intervention: F-18 FDG PET/CT

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 18 years old or over

• pathologically proven non-small cell lung cancer: adenocarcinoma or squamous cell carcinoma

• patients to be treated with immune checkpoint inhibitors (nivolumab or pembrolizumab or atezolizumab)

• ECOG performance status ≤ 2

• A person who have heard the detailed explanation of this clinical trial and are willing to voluntarily decide to participate and sign the informed consent form

Locations
Other Locations
Republic of Korea
Samsung Medical Center
RECRUITING
Seoul
Contact Information
Primary
Seung hwan Moon, M.D., Ph.D.
seunghwan.moons.moon@samsung.com
+82-2-3410-6293
Time Frame
Start Date: 2022-05-09
Estimated Completion Date: 2025-12
Participants
Target number of participants: 100
Treatments
Patients with NSCLC who will have FDG PET/CT before and during ICI Tx
There is no difference from the treatment schedule performed in usual clinical setting except for an additional F-18 FDG PET/CT scan. Detailed plan of ICI treatment and patient management (dose, administration date, treatment period, and follow-up) follows the standard protocol of our institution in this study.
Sponsors
Leads: Samsung Medical Center

This content was sourced from clinicaltrials.gov