Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
Interventional study with minimal risks and constraints, with evaluation of the incidence of lung cancers by low-dose thoracic CT scan without injection of contrast medium, of the immunological, inflammatory and metabolic blood profile and of the microbiota; systematic proposal of smoking cessation for active smokers or assistance in maintaining cessation.
• 1- All PREVALUNG or PREVALUNG ETOILE participants
• 2- Active or former smokers who have smoked daily for at least 10 years and have either atheromatous disease (coronary, lower limb, supra-aortic trunk, aortic, visceral or upper limb arteries) or a moderate or high coronary calcium score\*, \*\*.
• Age 45- 75 years and
• Medical follow-up for smoking-related atheromatous pathology and
• daily smoking for at least 10 years prior to disease (for smoking, there are no quantitative criteria or withdrawal times)
⁃ visual coronary calcium score quantified by a radiologist on a chest CT scan.
⁃ 3- Individuals at risk of lung cancer without atheromatous disease or moderate or high calcium score being managed for a tobacco-related disease (chronic bronchitis or non-progressive cancer \> 5 years) or with eligibility criteria for lung cancer screening (inclusion criteria in the NLST or NELSON studies or American recommendations)\*\*.
• Age 45- 75 and
• Medical follow-up for a smoking-related pathology:
• chronic obstructive pulmonary disease / emphysema, or
• history of non-progressive cancer \> 5 years, including ENT, lung, breast, cervix, excreto-urinary tract, bladder, esophagus, stomach, pancreas, liver, kidney, chronic myeloid leukemia.
‣ and
‣ \- daily smoking for at least 10 years prior to the disease (for smoking, there are no quantitative criteria or withdrawal periods).
‣ Or
• Age 55 - 74
• Cumulative smoking ≥ 30 pack-years
• active or weaned for less than 15 years Or
‣ NELSON inclusion criteria :
• Age 50-75
• Smoking :
• \> 15 cigarettes /D for more than 25 years or
• \> 10 cigarettes /D for more than 30 years
• active smoking or cessation \< 10 years Or
‣ American recommendations :
• Age 50 - 80
• Smoking ≥20 PA