• Active proliferative LN Class III or IV either with or without the presence of Class V according to the 2003 ISN/RPS classification

• Renal biopsy obtained within 6 months prior to signing the ICF or during Screening Period.

• Urine protein to creatinine ratio \> 1 mg/mg (113.17 mg/mmol)

• eGFR ≥ 35 mL/min/1.73 m2 (as calculated by the Chronic Kidney Disease Epidemiology Collaboration formula).

• Fulfills updated 2019 EULAR/ACR SLE classification criteria.

• No signs of symptoms of active TB prior to or during screening or no treatment for latent TB