• Histologically proven diagnosis of endometrial cancer based on endometrial sampling with a plan to undergo laparoscopic or robotic hysterectomy and lymphatic assessment as part of primary management. Biopsy must be performed within 90 days prior to registration

• Clinical stage I endometrial cancer based on the following diagnostic workup:

⁃ History/physical examination within 30 days prior to registration is reassuring for the absence of metastatic disease

• Age \>= 18 years

• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2

• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

• The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

• Patients must speak English or Spanish