Lymphocytic Colitis

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Lymphocytic Colitis?

Lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). As the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. In lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell) is observed. Signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. The underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. Treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery.

Top Global Doctors

Andreas Muench
Troy, AL
Gilles Macaigne
Jossigny, 11, FR
Johan Bohr
Oerebro, T, SE
Gian E. Tontini
Milan, 25, IT

Latest Research

Latest Advance
  • Condition: Refractory Microscopic Colitis (MC)
  • Journal: Journal of Crohn's & colitis
  • Treatment Used: Vedolizumab
  • Number of Patients: 11
  • Published —
This study evaluated clinical remission with vedolizumab in budesonide-refractory patients with microscopic colitis (inflammation of colon; MC).
Latest Advance
  • Condition: Induction Therapy For Lymphocytic Colitis
  • Journal: Gastroenterology
  • Treatment Used: budesonide versus mesalazine versus placebo
  • Number of Patients: 57
  • Published —
The purpose of the study was to evaluate budesonide and mesalazine as induction therapy for lymphocytic colitis.

Clinical Trials

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.