Learn About Lynch Syndrome

What is the definition of Lynch Syndrome?

Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (endometrial cancer). Women with Lynch syndrome have a higher overall risk of developing cancer than men with the condition because of these cancers of the female reproductive system. In individuals with Lynch syndrome who develop cancer, the cancer typically occurs in their forties or fifties.

What are the causes of Lynch Syndrome?

Changes in the MLH1, MSH2, MSH6, PMS2, or EPCAM gene have been found in people with Lynch syndrome.

How prevalent is Lynch Syndrome?

In the United States, it is estimated that 1 in 279 individuals have a genetic variant (also known as a mutation) associated with Lynch syndrome.

Is Lynch Syndrome an inherited disorder?

Lynch syndrome cancer risk is inherited in an autosomal dominant pattern, which means one inherited copy of the altered gene in each cell is sufficient to increase cancer risk. It is important to note that people with a variant have an increased risk of cancer; not all people who inherit variants in these genes will develop cancer.

Who are the top Lynch Syndrome Local Doctors?
Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

Salina Regional Health Center Inc

511 S Santa Fe Ave, 
Salina, KS 
 0.6 mi
Accepting New Patients
Offers Telehealth

Jeffrey Geitz is a Hematologist Oncology specialist and a Hematologist in Salina, Kansas. Dr. Geitz and is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. His top areas of expertise are Paget Disease of the Breast, Colorectal Cancer, Lynch Syndrome, Bone Marrow Aspiration, and Endoscopy. Dr. Geitz is currently accepting new patients.

Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

Salina Regional Health Center Inc

511 S Santa Fe Ave, 
Salina, KS 
 0.6 mi
Accepting New Patients
Offers Telehealth

Peeran Sandhu is a Hematologist Oncology specialist and a Hematologist in Salina, Kansas. Dr. Sandhu and is rated as an Advanced provider by MediFind in the treatment of Lynch Syndrome. His top areas of expertise are Paget Disease of the Breast, Lung Cancer, Adult Soft Tissue Sarcoma, Pleuropulmonary Blastoma, and Bone Marrow Aspiration. Dr. Sandhu is currently accepting new patients.

 
 
 
 
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Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology
Salina, KS 
 2.4 mi
Accepting New Patients

Larry Beck is a Hematologist Oncology specialist and a Hematologist in Salina, Kansas. Dr. Beck and is rated as an Experienced provider by MediFind in the treatment of Lynch Syndrome. His top areas of expertise are Childhood Acute Myeloid Leukemia, Acute Myeloid Leukemia (AML), Acute Myeloblastic Leukemia without Maturation, Lymphofollicular Hyperplasia, and Bone Marrow Aspiration. Dr. Beck is currently accepting new patients.

What are the latest Lynch Syndrome Clinical Trials?
Lynch Syndrome Integrative Epidemiology and Genetics (LINEAGE)

Summary: The vision of the Lynch syndrome INtegrative Epidemiology And GEnetics (LINEAGE) Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome. The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research. This consortium will provide intellectual and infrastructure support to facilitate dev...

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Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

Summary: This is a community-based study requiring participant-self-enrollment, that can help to increase the rates of genetic testing among the family members of people who have been diagnosed with a hereditary cancer syndrome. The two main factors in this study are the IGNITE-TX intervention (website and navigator) and the free genetic counseling and testing. The IGNITE-TX Intervention is an innovative m...

Who are the sources who wrote this article ?

Published Date: April 15, 2021
Published By: National Institutes of Health