Lynch SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Lynch Syndrome
Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer. This includes cancers of the colon and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, urinary tract, brain, and skin. Additionally, women with this disorder have an increased risk of cancer of the ovaries and the lining of the uterus (endometrial cancer). Women with Lynch syndrome have a higher overall risk of developing cancer than men with the condition because of these cancers of the female reproductive system. In individuals with Lynch syndrome who develop cancer, the cancer typically occurs in their 40s or 50s.
Variants that cause a disease or increase the risk for a disease are sometimes called pathogenic variants. Pathogenic variants in the MLH1, MSH2, MSH6, PMS2, or EPCAM genes can cause Lynch syndrome.
In the United States, it is estimated that 1 in 279 individuals have a genetic variant (also known as a mutation) that is associated with Lynch syndrome.
Lynch syndrome is typically inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase the risk of cancer. Although people with Lynch syndrome have a higher risk of cancer, not all people with Lynch syndrome will develop cancer.
Abingdon Physician Partners - Regional Cancer Center At Johnston Memorial Hospital
. Dr. Davis is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. His top areas of expertise are Hemangioma Thrombocytopenia Syndrome, Familial Colorectal Cancer, Thrombocytopenia, and Colorectal Cancer.
Ballad Health Cancer Care
. Dr. Musgrave is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. Her top areas of expertise are Paget Disease of the Breast, Thrombocytopenia, Neuroendocrine Tumor, and Angiosarcoma.
Rockefeller Outpatient Pavilion
Martin Weiser is a Colorectal Surgeon in New York, New York. Dr. Weiser is rated as an Elite provider by MediFind in the treatment of Lynch Syndrome. His top areas of expertise are Colorectal Cancer, Anal Cancer, Lynch Syndrome, Ileostomy, and Colostomy.
Summary: NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility...
Summary: This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public. Researchers hope to learn the value of providing broad, public-wide testing for high risk cancer types (like hereditary breast and ovarian cancer or Lynch syndromes) instead of only testing people whose families are...
Published Date: April 15, 2021
Published By: National Institutes of Health