Lynch SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Lynch Syndrome
Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer. This includes cancers of the colon and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, urinary tract, brain, and skin. Additionally, women with this disorder have an increased risk of cancer of the ovaries and the lining of the uterus (endometrial cancer). Women with Lynch syndrome have a higher overall risk of developing cancer than men with the condition because of these cancers of the female reproductive system. In individuals with Lynch syndrome who develop cancer, the cancer typically occurs in their 40s or 50s.
Variants that cause a disease or increase the risk for a disease are sometimes called pathogenic variants. Pathogenic variants in the MLH1, MSH2, MSH6, PMS2, or EPCAM genes can cause Lynch syndrome.
In the United States, it is estimated that 1 in 279 individuals have a genetic variant (also known as a mutation) that is associated with Lynch syndrome.
Lynch syndrome is typically inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase the risk of cancer. Although people with Lynch syndrome have a higher risk of cancer, not all people with Lynch syndrome will develop cancer.
Sentara Surgery Specialists
John Sayles is a General Surgeon and a Colorectal Surgeon practicing medicine in Norfolk, Virginia. Dr. Sayles is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 23 other conditions, according to our data. His clinical expertise encompasses Familial Colorectal Cancer, Anal Cancer, Colorectal Cancer, Hernia Surgery, and Ileostomy. Dr. Sayles is board certified in American Board Of Surgery - Surgery (General Surgery) - 2028 and American Board Of Colon & Rectal Surgery - Colon & Rectal Surgery - 2029. Dr. Sayles is currently accepting new patients.
John Hopper practices practicing medicine in Carlton, Australia. Mr. Hopper is rated as an Elite expert by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 18 other conditions, according to our data. His clinical expertise encompasses Lynch Syndrome, Familial Colorectal Cancer, Breast Cancer, Oophorectomy, and Salpingo-Oophorectomy.
Lumc
Hans Vasen practices practicing medicine in Leiden, Netherlands. Mr. Vasen is rated as an Elite expert by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 11 other conditions, according to our data. His clinical expertise encompasses Lynch Syndrome, Familial Pancreatic Cancer, Familial Adenomatous Polyposis, Colonoscopy, and Endoscopy.
Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk for prostate cancer.
Summary: The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus. The study also tests if people with LS are willing and able to collect these samples themselves and whether they find the process acceptable. The main questions this study asks are: * Will peo...
Published Date: April 15, 2021
Published By: National Institutes of Health