Lynch SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Lynch Syndrome
Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer. This includes cancers of the colon and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, urinary tract, brain, and skin. Additionally, women with this disorder have an increased risk of cancer of the ovaries and the lining of the uterus (endometrial cancer). Women with Lynch syndrome have a higher overall risk of developing cancer than men with the condition because of these cancers of the female reproductive system. In individuals with Lynch syndrome who develop cancer, the cancer typically occurs in their 40s or 50s.
Variants that cause a disease or increase the risk for a disease are sometimes called pathogenic variants. Pathogenic variants in the MLH1, MSH2, MSH6, PMS2, or EPCAM genes can cause Lynch syndrome.
In the United States, it is estimated that 1 in 279 individuals have a genetic variant (also known as a mutation) that is associated with Lynch syndrome.
Lynch syndrome is typically inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase the risk of cancer. Although people with Lynch syndrome have a higher risk of cancer, not all people with Lynch syndrome will develop cancer.
Dana-Farber Brigham Cancer Center At Milford Regional Medical Center
Matthew Yurgelun is an Oncologist practicing medicine in Milford, Massachusetts. Dr. Yurgelun is rated as an Elite provider by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 19 other conditions, according to our data. His clinical expertise encompasses Lynch Syndrome, Familial Pancreatic Cancer, Pancreatic Cancer, Colonoscopy, and Endoscopy.
Advocate Lutheran General Cancer Institute
Edward James is a Hematologist and an Oncologist practicing medicine in Park Ridge, Illinois. Dr. James is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Colorectal Cancer, Familial Colorectal Cancer, Pancreatic Cancer, Familial Pancreatic Cancer, and Gastrostomy. Dr. James is board certified in American Board Of Internal Medicine, Medical Oncology.
Abingdon Physician Partners - Regional Cancer Center At Johnston Memorial Hospital
Timothy Davis is an Internal Medicine provider practicing medicine in Abingdon, Virginia. Dr. Davis is rated as a Distinguished provider by MediFind in the treatment of Lynch Syndrome. He is also highly rated in 38 other conditions, according to our data. His clinical expertise encompasses Hemangioma Thrombocytopenia Syndrome, Familial Colorectal Cancer, Thrombocytopenia, and Colorectal Cancer. Dr. Davis is board certified in American Board Of Internal Medicine.
Summary: NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility...
Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk for prostate cancer.
Published Date: April 15, 2021
Published By: National Institutes of Health