What is the definition of Macroamylasemia?

Macroamylasemia is the presence of an abnormal substance called macroamylase in the blood.

What are the causes for Macroamylasemia?

Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.

Most people with macroamylasemia do not have a serious disease that is causing it, but the condition has been associated with:

  • Celiac disease
  • Lymphoma
  • HIV infection
  • Monoclonal gammopathy
  • Rheumatoid arthritis
  • Ulcerative colitis

What are the symptoms for Macroamylasemia?

Macroamylasemia does not cause symptoms.

REFERENCES

Frasca JD, Velez MJ. Acute pancreatitis. In: Parsons PE, Wiener-Kronish JP, Stapleton RD, Berra L, eds. Critical Care Secrets. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 52.

Siddiqi HA, Salwen MJ, Shaikh MF, Bowne WB. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 22.

Tenner S, Steinberg WM. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 58.