Tissue Destruction and Healing in Celiac Disease
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate better resources to advance celiac disease patient care.
⁃ Gluten challenge group:
• Age 18 to 75 years old
• Diagnosis of Celiac disease for at least 12 months by intestinal biopsy
• Follow a strict gluten-free diet for at least the 12 consecutive months
⁃ Gluten de-challenge group:
• Age 18 to 75 years old
• Showing typical celiac disease symptoms
• Not on a gluten-free diet
⁃ Control group:
• Age 18 to 75 years old
• Females who are not pregnant