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Generic Name

Atovaquone

Brand Names

Malarone, Mepron

FDA approval date: February 28, 1995

Classification: Antimalarial

Form: Tablet, Suspension

What is Malarone (Atovaquone)?

Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported.

Approved To Treat

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Phase II Clinical Trial Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer

Enrollment Status: Recruiting

Publish Date: September 11, 2025

Intervention Type: Procedure, Drug

Study Phase: Phase 2

Summary: This phase II trial test tests how well repurposing atovaquone works in treating patients with platinum-resistant ovarian cancer. Atovaquone is used for the treatment or prevention of certain infections. Atovaquone is in a class of medications called antiprotozoal agents. It works by stopping the growth of certain types of protozoa that can cause pneumonia. Giving atovaquone may be effective in tr...

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Enrollment Status: Recruiting

Publish Date: July 22, 2025

Intervention Type: Radiation, Drug

Study Phase: Phase 1

Summary: The goal of this interventional study is to Assess the safety and tolerability of atovaquone in combination with standard radiation therapy (RT) for the treatment of pediatric patients with newly diagnosed pediatric high-grade glioma/diffuse midline glioma/diffuse intrinsic pontine glioma (pHGG/DMG/DIPG). The secondary aim is to assess the safety and tolerability of longer-term atovaquone treatmen...

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