Learn About Malignant Germ Cell Tumor

View Main Condition: Brain Tumor

What is the definition of Malignant Germ Cell Tumor?
Malignant germ cell tumors are rare cancerous masses that can grow in the ovaries in girls and testes in boys as well as other parts of the body, such as the chest, abdomen, lower back, and brain. There are several types of malignant germ cell tumors, such as teratomas, germinomas, endodermal sinus tumor or yolk sac tumors, choriocarcinoma, and embryonal carcinoma.
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What are the symptoms of Malignant Germ Cell Tumor?
Symptoms of malignant germ cell tumors depend on the size and location of the tumor and may include a solid testicular mass, with or without pain, in boys; a solid ovarian mass with abdominal pain in girls; a mass on the lower back or near the anus in an infant; a mass in the chest with associated respiratory distress; early puberty or vaginal bleeding at a very young age; constipation; incontinence; leg weakness; and abnormal testicular size or shape.
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What are the current treatments for Malignant Germ Cell Tumor?
Treatment for malignant germ cell tumors depends on the size and location of the tumor as well how advanced the cancer is and may include surgery, radiation therapy, chemotherapy (cisplation, etoposide, and bleomycin), hormonal replacement, and bone marrow transplantation. Treatment for relapsed malignant germ cell tumors may include additional chemotherapy with paclitaxel, ifosfamide, and carboplation followed by autologous stem cell transplantation.
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What are the latest Malignant Germ Cell Tumor Clinical Trials?
A First-in-Human, Phase 1/2, Dose Escalation Study of BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors

Summary: This is a first-in-human (FIH), Phase 1, open-label, multicenter study to assess safety and determine the recommended Phase 2 dose (RP2D) of BOXR1030 administration after lymphodepleting chemotherapy (LD chemotherapy) in subjects with glypican-3 positive (GPC3+) advanced solid tumors.

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A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors

Summary: This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in di...

What are the Latest Advances for Malignant Germ Cell Tumor?
Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center.
Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
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Surgical Resection of a Third Ventricle Nongerminomatous Germ Cell Tumor: Two-Dimensional Operative Video.