Learn About Malignant Germ Cell Tumor

What is the definition of Malignant Germ Cell Tumor?
Malignant germ cell tumors are rare cancerous masses that can grow in the ovaries in girls and testes in boys as well as other parts of the body, such as the chest, abdomen, lower back, and brain. There are several types of malignant germ cell tumors, such as teratomas, germinomas, endodermal sinus tumor or yolk sac tumors, choriocarcinoma, and embryonal carcinoma.
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What are the symptoms of Malignant Germ Cell Tumor?
Symptoms of malignant germ cell tumors depend on the size and location of the tumor and may include a solid testicular mass, with or without pain, in boys; a solid ovarian mass with abdominal pain in girls; a mass on the lower back or near the anus in an infant; a mass in the chest with associated respiratory distress; early puberty or vaginal bleeding at a very young age; constipation; incontinence; leg weakness; and abnormal testicular size or shape.
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What are the current treatments for Malignant Germ Cell Tumor?
Treatment for malignant germ cell tumors depends on the size and location of the tumor as well how advanced the cancer is and may include surgery, radiation therapy, chemotherapy (cisplation, etoposide, and bleomycin), hormonal replacement, and bone marrow transplantation. Treatment for relapsed malignant germ cell tumors may include additional chemotherapy with paclitaxel, ifosfamide, and carboplation followed by autologous stem cell transplantation.
Who are the top Malignant Germ Cell Tumor Local Doctors?
MM
Matthew J. Murray
Elite
Highly rated in
8
conditions

University Of Cambridge

Cambridge, ENG, GB 

Matthew Murray is in Cambridge, United Kingdom. Murray is rated as an Elite expert by MediFind in the treatment of Malignant Germ Cell Tumor. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Malignant Germ Cell Tumor, Testicular Cancer, Testicular Yolk Sac Tumor, and Malignant Teratoma of the Mediastinum.

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FS
Furqan Shaikh
Elite
Highly rated in
7
conditions

The Hospital For Sick Children

Toronto, ON, CA 

Furqan Shaikh is in Toronto, Canada. Shaikh is rated as an Elite expert by MediFind in the treatment of Malignant Germ Cell Tumor. He is also highly rated in 7 other conditions, according to our data. His top areas of expertise are Malignant Germ Cell Tumor, Retinoblastoma, Hepatoblastoma, and Hereditary Retinoblastoma.

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DB
Dr. Deborah F. Billmire
General Surgery | Pediatric Surgery
Distinguished
Highly rated in
7
conditions
General Surgery
Pediatric Surgery

Riley Pediatric Surgery

Indianapolis, IN 

Deborah Billmire is a General Surgeon and a Pediatric Surgeon in Indianapolis, Indiana. Dr. Billmire has been practicing medicine for over 43 years and is rated as a Distinguished doctor by MediFind in the treatment of Malignant Germ Cell Tumor. She is also highly rated in 7 other conditions, according to our data. Her top areas of expertise are Malignant Germ Cell Tumor, Testicular Yolk Sac Tumor, Tracheoesophageal Fistula, and Malignant Teratoma of the Mediastinum. She is board certified in General Surgery and licensed to treat patients in Indiana. Dr. Billmire is currently accepting new patients.

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What are the latest Malignant Germ Cell Tumor Clinical Trials?
Study of 2-hydroxyoleic Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors
Who is this study for: Child patients with Glioma
Status: Recruiting
Start Date: September 1, 2020
Intervention Type: Drug
Phase: Phase 1/Phase 2
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Summary: An open label, non-randomized study in pediatric patients with advanced high-grade gliomas and other solid tumors.~The study will be performed in two phases: a dose escalation phase in up to 18 patients following a standard 3+3 design to establish dose-limiting toxicity (DLT) and a safe dose of 2-OHOA followed by an expanded safety cohort of up to 10 patients treated at the Maximum Tolerated Dose ...
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Phase II Study of Binimetinib With Encorafenib in Patients With Metastatic Melanoma and CNS Metastases
Status: Not yet recruiting
Start Date: September 1, 2021
Intervention Type: Drug, Other
Study Drugs: Encorafenib, Binimetinib
Phase: Phase 2
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Summary: This phase II trial studies the effects of binimetinib and encorafenib in treating patients with melanoma that has spread to the central nervous system (metastases). Binimetinib and encorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving binimetinib and encorafenib may help control melanoma that has spread to the brain.
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What are the Latest Advances for Malignant Germ Cell Tumor?
Clinical, therapeutic and prognostic aspects of malignant germ cell tumors of the ovary: experience of 21 years old Tunisian.
Journal: The Pan African medical journal
Published: September 21, 2020
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Summary: Clinical, therapeutic and prognostic aspects of malignant germ cell tumors of the ovary: experience of 21 years old Tunisian.
Seminoma with focal gonadoblastoma in anatomically normal male: A rare case report.
Condition: Seminoma with Focal Gonadoblastoma in Anatomically Normal Male
Journal: Indian journal of pathology & microbiology
Treatment Used: High Left Inguinal Orchidectomy
Number of Patients: 1
Published: August 10, 2020
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Summary: This case report describes a 37-year-old male diagnosed with seminoma with focal gonadoblastoma treated with high left inguinal orchiectomy (removal of testicle).
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Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience.
Condition: Malignant Germ Cell Tumor
Journal: Pediatric blood & cancer
Treatment Used: Second-Line Conventional Chemotherapy (SLCT)
Number of Patients: 21
Published: December 19, 2019
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Summary: This study tested the safety and efficacy of using SLCT to treat patients with malignant germ cell tumors.
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