Malignant Germ Cell Tumor Symptoms, Doctors, Treatments, Advances & More

Learn About Malignant Germ Cell Tumor

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What is the definition of Malignant Germ Cell Tumor?

Malignant germ cell tumors are rare cancerous masses that can grow in the ovaries in girls and testes in boys as well as other parts of the body, such as the chest, abdomen, lower back, and brain. There are several types of malignant germ cell tumors, such as teratomas, germinomas, endodermal sinus tumor or yolk sac tumors, choriocarcinoma, and embryonal carcinoma.

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What are the symptoms of Malignant Germ Cell Tumor?

Symptoms of malignant germ cell tumors depend on the size and location of the tumor and may include a solid testicular mass, with or without pain, in boys; a solid ovarian mass with abdominal pain in girls; a mass on the lower back or near the anus in an infant; a mass in the chest with associated respiratory distress; early puberty or vaginal bleeding at a very young age; constipation; incontinence; leg weakness; and abnormal testicular size or shape.

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What are the current treatments for Malignant Germ Cell Tumor?

Treatment for malignant germ cell tumors depends on the size and location of the tumor as well how advanced the cancer is and may include surgery, radiation therapy, chemotherapy (cisplation, etoposide, and bleomycin), hormonal replacement, and bone marrow transplantation. Treatment for relapsed malignant germ cell tumors may include additional chemotherapy with paclitaxel, ifosfamide, and carboplation followed by autologous stem cell transplantation.

Who are the top Malignant Germ Cell Tumor Local Doctors?

Furqan A. Shaikh

Elite

Highly rated in

conditions

Hospital For Sick Children

Toronto, ON, CA

Furqan Shaikh practices in Toronto, Canada. Shaikh is rated as an Elite expert by MediFind in the treatment of Malignant Germ Cell Tumor. He is also highly rated in 9 other conditions, according to our data. His top areas of expertise are Malignant Germ Cell Tumor, Retinoblastoma, Testicular Yolk Sac Tumor, Hepatoblastoma, and Liver Transplant.

Dr. Farzana D. Pashankar

Pediatric Hematology Oncology | Pediatrics

Elite

Highly rated in

conditions

Pediatric Hematology Oncology
Pediatrics

Yale New Haven Health System

Pediatric Specialty Center

5520 Park Ave,

Trumbull, CT

Farzana Pashankar is a Pediatric Hematologist Oncology specialist and a Pediatrics expert in Trumbull, Connecticut. Pashankar has been practicing medicine for over 34 years and is rated as an Elite expert by MediFind in the treatment of Malignant Germ Cell Tumor. She is also highly rated in 8 other conditions, according to our data. Her top areas of expertise are Malignant Germ Cell Tumor, Malignant Teratoma of the Mediastinum, Sickle Cell Disease, Bone Marrow Aspiration, and Bone Marrow Transplant. She is licensed to treat patients in Connecticut. Pashankar is currently accepting new patients.

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Dr. James F. Amatruda

Pediatric Hematology Oncology | Pediatric Infectious Disease

Elite

Highly rated in

conditions

Pediatric Hematology Oncology
Pediatric Infectious Disease

Los Angeles Office

4650 Sunset Blvd,

Los Angeles, CA

James Amatruda is a Pediatric Hematologist Oncology specialist and a Pediatric Infectious Disease expert in Los Angeles, California. Amatruda is rated as an Elite expert by MediFind in the treatment of Malignant Germ Cell Tumor. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Malignant Germ Cell Tumor, Malignant Teratoma of the Mediastinum, Ewing Sarcoma, Osteosarcoma, and Orchiectomy. He is licensed to treat patients in Texas.

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What are the latest Malignant Germ Cell Tumor Clinical Trials?

A First-in-Human, Phase 1/2, Dose Escalation Study of BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors

Enrollment Status: Recruiting

Publish Date: December 15, 2022

Intervention Type: Biological

Study Phase: Phase 1/Phase 2

Summary: This is a first-in-human (FIH), Phase 1, open-label, multicenter study to assess safety and determine the recommended Phase 2 dose (RP2D) of BOXR1030 administration after lymphodepleting chemotherapy (LD chemotherapy) in subjects with glypican-3 positive (GPC3+) advanced solid tumors.

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A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors

Who is this study for: Patients with Tumor, Teratoma

Enrollment Status: Recruiting

Publish Date: December 15, 2022

Intervention Type: Drug, Procedure

Study Drugs: PaclitaxelIfosfamideCisplatinPegylated G-CSFG-CSFCarboplatinEtoposide Phosphate

Study Phase: Phase 3

Summary: This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in di...

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What are the Latest Advances for Malignant Germ Cell Tumor?