What is the definition of Malignant Mixed Mullerian Tumor?

A malignant mixed müllerian tumor (MMMT), also called a carcinosarcoma, is a type of cancer that contains two types of cancer cells - carcinoma and sarcoma cells. These tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. The majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. Very rarely, MMMTs can develop in the female peritoneum (lining of the abdominal wall).

What are the alternative names for Malignant Mixed Mullerian Tumor?

  • Mixed tumor, Mullerian
  • Mixed Mullerian tumor
  • Carcinosarcoma
  • MMMT

What are the causes for Malignant Mixed Mullerian Tumor?

Presently, most mixed Mullerian tumors (MMMT) are thought to occur by chance without an association to a genetic predisposition.  There have been rare reports of MMMT of the uterus developing in individuals with Lynch syndrome, an inherited condition in which individuals have a genetic predisposition to develop certain cancers including uterine cancer.  One article in the medical literature describes two cases of MMMT of the ovary in women with personal and family histories of breast cancer, and the authors state that these cases of MMMT of the ovary are suggestive of hereditary breast-ovarian cancer syndrome.  As such, these authors state that genetic testing should be considered in women with MMMT of the ovary.  Overall, there is currently very little information about the cause of MMMT.

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