Testing the Effect of a Plant-based, Protein-dense Sauce (ProSauce) on Metabolic Availability of Essential Amino Acids and Gut Fullness and Satiety in Older Adults

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein sauce without resulting in excessive gut fullness and satiety. The main questions it aims to answer are: Does meals with high-protein sauce deliver better metabolic availability of amino acid profile? Does this high-protein sauce also not lead to excessive appetite suppression due to its liquid form? Researchers will compare high protein sauce to a commercially available standard low protein sauce. Participants will consume two meals, either protein-fortified or standard low-protein sauce, in a randomised order with at least a one-week washout period between each meal. The investigators will collect venous blood samples over a 6-hour postprandial period to measure plasma essential (and non-essential) amino acid and insulin concentrations. The investigators will also measure appetite-related hormones from venous plasma and assess subjective appetite using a visual analogue scale, taken in parallel with the blood sample time points.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: t
View:

• Aged 60 and over

• Living independently in the community

• Capacity to provide informed consent

• Non-smoking (vaping is considered smoking)

• No known medical conditions that might influence the study outcomes, e.g., heart disease, diabetes mellitus, obesity, disthyroidism and other endocrinopathies and renal failure

• Not taking any medications that might influence the study outcomes e.g., taking anabolic steroids or corticosteroids long term

• No clinically diagnosed eating disorders

• No severe dislike or allergy to any of the study food

• No hospitalisations in the last 6 months

• Not dieting and weight stable for 3 months before the study (\< 3 kg change in weight)

Locations
Other Locations
United Kingdom
University of Exeter
RECRUITING
Exeter
Contact Information
Primary
Zhuoxiu Jin, Dr
z.jin3@exeter.ac.uk
+447529283410
Backup
Joanna Bowtell, Prof
Time Frame
Start Date: 2025-07-10
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 20
Treatments
Experimental: ProSauce
Placebo_comparator: standard sauce
Related Therapeutic Areas
Sponsors
Leads: University of Exeter

This content was sourced from clinicaltrials.gov