The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Manifestation of Starvation Ketosis and Ketoacidosis in Patients With Nonalcoholic Steatohepatitis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates. Insufficient production of ketone bodies reduces the rate of weight loss, and excessive amounts of ketones can lead to ketoacidosis or liver failure in patients with nonalcoholic steatohepatitis (NASH). The investigators hypothesize that weight loss is directly related to calorie intake, and a significant reduction in carbohydrate content leads to increased ketosis and the risk of ketoacidosis.

Objectives: The study aimed to compare the incidence of ketoacidosis and liver failure in patients with NASH with different intakes of carbohydrates in the early postoperative period after gastric bypass. In addition, the investigators want to find out how carbohydrate restriction will affect weight loss for up to 1 year.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• obesity patients BMI 30-50 kg/m2.

• patients with nonalcoholic steatohepatitis (NASH).

Locations
Other Locations
Kazakhstan
Oral Ospanov
RECRUITING
Astana
Contact Information
Primary
Oral Ospanov, PhD
bariatric.kz@gmail.com
7015287734
Backup
Bakhtiyar Yelembayev
elembaevbaha@gmail.com
7071302383
Time Frame
Start Date: 2024-03-25
Estimated Completion Date: 2025-08-01
Participants
Target number of participants: 150
Treatments
Experimental: Carbohydrate Restriction after a Gastric Bypass: 51-75% deficit in carbohydrates
In the postoperative period, the amount of carbohydrate intake was reduced by counting carbohydrates in a glucose solution in the first three days after surgery and counting carbohydrates in food. Created a carbohydrate deficit of 51-75%.
Active_comparator: Carbohydrate Restriction after a Gastric Bypass: 26-50% deficit in carbohydrates
In the postoperative period, the amount of carbohydrate intake was reduced by counting carbohydrates in a glucose solution in the first three days after surgery and counting carbohydrates in food. Created a carbohydrate deficit: 26-50% deficit in carbohydrates.
Active_comparator: Carbohydrate Restriction after a Gastric Bypass:1-25% deficit in carbohydrates
In the postoperative period, the amount of carbohydrate intake was reduced by counting carbohydrates in a glucose solution in the first three days after surgery and counting carbohydrates in food. Created a carbohydrate deficit:1-25% deficit in carbohydrates.
Sponsors
Leads: The Society of Bariatric and Metabolic Surgeons of Kazakhstan

This content was sourced from clinicaltrials.gov