• Age 18-75 years old, no gender limit;

• Histologically diagnosed as diffuse large B-cell lymphoma (DLBCL), transforming follicular lymphoma (TFL), primary mediastinal B-cell lymphoma (PMBCL), mantle cell lymphoma (MCL) and other inert B-cells NHL conversion type:

∙ Refractory or relapsed DLBCL refers to the failure to achieve complete remission after 2-line treatment; disease progression during any treatment, or disease stable time equal to or less than 6 months; or disease progression or recurrence within 12 months after autologous hematopoietic stem cell transplantation ；

‣ Refractory or relapsed MCL must be resistant to or intolerable to BTK inhibitors;

‣ Refractory or relapsed indolent B-cell NHL is the failure or recurrence of third-line treatment;

• Previous treatment must include CD20 monoclonal antibody treatment (unless the subject is CD20 negative) and anthracyclines;

• At least one measurable lesion with the longest diameter ≥ 1.5 cm exists;

• The expected survival period is ≥12 weeks;

• The puncture section of the tumor tissue was positive for CD19 expression;

• ECOG score 0-2 points;

• Sufficient organ function reserve:

∙ Alanine aminotransferase, aspartate aminotransferase ≤ 2.5× UNL (upper limit of normal value);

‣ Creatinine clearance rate (Cockcroft-Gault method) ≥60 mL/min;

‣ Serum total bilirubin and alkaline phosphatase ≤1.5× UNL;

‣ Glomerular filtration rate\>50Ml/min

‣ Cardiac ejection fraction (EF) ≥50%;

‣ Under natural indoor air environment, basic oxygen saturation\>92%

• Allow a previous stem cell transplantation

⁃ The approved anti-B-cell lymphoma treatments, such as systemic chemotherapy, systemic radiotherapy, and immunotherapy, have been completed for at least 3 weeks before the study medication;

⁃ Allow patients who have previously received CAR-T cell therapy and have failed or relapsed after 3 months of evaluation;

⁃ Female subjects of childbearing age must have a negative pregnancy test and agree to take effective contraceptive measures during the trial

⁃ Two tests for the new coronavirus or swine flu virus are negative.