Treatments for mantle cell lymphoma depend on the stage of the disease and the patient’s overall health, but generally involve a combination of chemotherapy and immunotherapy drugs and radiation therapy. Stem cell transplant may also be used in some select patients.
Chemotherapy – Chemotherapy uses drugs that kill cancer cells and is often combined with immunotherapy drugs for the treatment of mantle cell lymphoma. Chemotherapy may be administered orally (pill), intravenously (IV), or in severe cases, intrathecally (directly into the spinal fluid; methotrexate) and is given in cycles.
Chemotherapy drugs for mantle cell lymphoma may also be given in combinations as drug regimens also in combination with corticosteroids, such as cyclophosphamide (Cytotoxan), vincristine (Oncovin), and prednisone (Deltasone), known as CVP, or cyclophosphamide, doxorubicin (Adriamycin), hydroxydaunorubicin (Rubex), vincristine (Oncovin), and prednisone (Deltasone), known as CHOP, as well as other combination regimens.
Immunotherapy (Biological therapy) – Immunotherapy drugs use the patient’s immune system to attack cancer cells or to prevent them from growing and are often used for mantle cell lymphoma in combination with chemotherapy drugs, such as chemotherapy plus rituximab (Rituxan) or bortezomib (Velcade), for relapsed or untreated mantle cell lymphoma, or ibrutinib (Imbruvica), also for relapsed mantle cell lymphoma, or acalabrutinib (Calquence), for mantle cell lymphoma that has had at least one treatment, or lenolidomide (Revlimid), for relapsed or progressed mantle cell lymphoma after two prior therapies.
Radiation therapy – Radiation therapy uses high-energy X-rays or protons to kill cancer cells and shrink tumors and may be administered for early or advanced stage mantle cell lymphoma.
Stem cell transplant (Bone marrow transplant) – Different forms of stem cell transplantation may be used to treat mantle cell lymphoma in first complete remission. Stem cell transplantation uses bone marrow stem cells that are infused into the patient to help create new, healthy cells after using chemotherapy and irradiation to kill the unhealthy cells and may include for mantle cell carcinoma either autologous stem cell transplantation or reduced intensity allogenic stem cell transplantation, depending on the availability of a matched donor.