• 18 years

‣ Histopathologically confirmed mantle cell lymphoma according to the 5th edition of the World Health Organization (WHO)

⁃ FISH with del(17p)/TP53 mutation or ≥65 years; or\<65 years but chemotherapy intolerance;

⁃ Life expectancy of \> 3 months (in the opinion of the investigator);

⁃ Creatinine Clearance Rate (CCR) ≥ 50 mL/min or estimated Glomerular Filtration ●Rate (eGFR) ≥ 60 mL/(min·1.73 m\^2);

⁃ International Normalized Ratio (INR) ≤ 1.5 and activated Partial Thromboplastin Time (aPTT) ≤ 1.5 times the upper limit of normal;

⁃ Left Ventricular Ejection Fraction (LVEF) ≥ 50%;

⁃ Agreeing to provide written informed consent prior to any special examination or procedure for the research on their own or legal representative.