Learn About Marchiafava Bignami Disease

What is the definition of Marchiafava Bignami Disease?
Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown.
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What are the alternative names for Marchiafava Bignami Disease?
  • Marchiafava Bignami disease
  • Acute Marchiafava-Bignami disease
  • Chronic Marchiafava-Bignami syndrome
  • MBD
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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