Marginal Zone Lymphoma (MZL) Overview

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Learn About Marginal Zone Lymphoma (MZL)

What is the definition of Marginal Zone Lymphoma (MZL)?
Marginal zone lymphoma refers to a group of slow-growing non-Hodgkin B-cell lymphomas. Marginal zone lymphomas form in the marginal zone of lymphatic tissues, which include the spleen, lymph nodes, and other lymphoid tissue that contains B cells. B cells are a type of white blood cell. There are three types of marginal zone lymphomas: 1) extranodal marginal zone lymphoma, which most often occurs in the stomach; 2) mucosa-associated lymphoid tissue lymphoma; and 3) splenic marginal zone lymphoma.
What are the symptoms of Marginal Zone Lymphoma (MZL)?
Some patients with marginal zone lymphoma may not have any symptoms. Symptoms of marginal zone lymphoma include widespread swollen lymph nodes, fatigue, unexplained weight loss, fever, night sweats, and anemia.
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What are the current treatments for Marginal Zone Lymphoma (MZL)?
Treatment for marginal zone lymphoma is individualized, depending on the type. Some patients with marginal zone lymphoma may not require any treatment at first, just watchful waiting. Treatment for marginal zone lymphoma may include radiotherapy; rituximab; immunochemotherapy with rituximab plus chemotherapy, with or without an anthracycline, or bendamustine/chlorambucil; B cell receptor inhibitors, such as ibrutinib; immodulatory agents, such as lenalidomide; and phosphoinositide 3-kinase inhibitors, such as copanlisib and umbralisib.
Who are the top Marginal Zone Lymphoma (MZL) Local Doctors?
Experienced in Marginal Zone Lymphoma (MZL)
Dr. Elizabeth A. Connelly
Hematology Oncology | Hematology | Oncology
Experienced in Marginal Zone Lymphoma (MZL)
Dr. Elizabeth A. Connelly
Hematology Oncology | Hematology | Oncology

Billings Clinic

1301 15th Ave W, 
Williston, ND 
 (1.8 mi)
701-774-7400
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Elizabeth Connelly is a Hematologist Oncology specialist and a Hematologist in Williston, North Dakota. Dr. Connelly and is rated as an Experienced provider by MediFind in the treatment of Marginal Zone Lymphoma (MZL). Her top areas of expertise are Inflammatory Breast Cancer, Breast Cancer, Angiosarcoma, and Paget Disease of the Breast. Dr. Connelly is currently accepting new patients.

Gerald G. Gross
Advanced in Marginal Zone Lymphoma (MZL)
Dr. Gerald G. Gross
Hematology Oncology | Hematology | Oncology
Advanced in Marginal Zone Lymphoma (MZL)
Dr. Gerald G. Gross
Hematology Oncology | Hematology | Oncology

Sanford Medical Center Fargo

801 Broadway N, 
Fargo, ND 
 (331.3 mi)
701-234-2000
Languages Spoken:
English, German
See accepted insurances
Accepting New Patients

Gerald Gross is a Hematologist Oncology specialist and a Hematologist in Fargo, North Dakota. Dr. Gross and is rated as an Advanced provider by MediFind in the treatment of Marginal Zone Lymphoma (MZL). His top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Relapsed Refractory Multiple Myeloma (RRMM), Multiple Myeloma, Chronic Lymphocytic Leukemia (CLL), and Bone Marrow Aspiration. Dr. Gross is currently accepting new patients.

 
 
 
 
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Advanced in Marginal Zone Lymphoma (MZL)
Dr. Anil Potti
Hematology Oncology | Oncology | Hematology
Advanced in Marginal Zone Lymphoma (MZL)
Dr. Anil Potti
Hematology Oncology | Oncology | Hematology

William Noyes MD PC

1451 44th Ave S, Suite E, 
Grand Forks, ND 
 (304.7 mi)
701-787-5800
Languages Spoken:
English, Hindi
See accepted insurances
Accepting New Patients
Offers Telehealth

Anil Potti is a Hematologist Oncology specialist and an Oncologist in Grand Forks, North Dakota. Dr. Potti and is rated as an Advanced provider by MediFind in the treatment of Marginal Zone Lymphoma (MZL). His top areas of expertise are Iron Deficiency Anemia, Childhood Iron Deficiency Anemia, Lung Cancer, Pleuropulmonary Blastoma, and Bone Marrow Aspiration. Dr. Potti is currently accepting new patients.

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What are the latest Marginal Zone Lymphoma (MZL) Clinical Trials?
A Pivotal Phase 3 Clinical Trial to Assess the Diagnostic Performance and Safety of [68Ga]Ga-PentixaFor ([68Ga]Ga-PTF), a Positron Emission Tomography (PET) Imaging Agent, Versus [18F]FDG PET/CT Imaging, for Staging of Patients with Confirmed Marginal Zone Lymphoma Exemplary for CXCR4-positive Malignant Lymphomas: a Prospective, International, Multi-center, Comparative, Randomized, Cross-over, Open-label Lymphoma Diagnostic Trial
A Pivotal Phase 3 Clinical Trial to Assess the Diagnostic Performance and Safety of [68Ga]Ga-PentixaFor ([68Ga]Ga-PTF), a Positron Emission Tomography (PET) Imaging Agent, Versus [18F]FDG PET/CT Imaging, for Staging of Patients with Confirmed Marginal Zone Lymphoma Exemplary for CXCR4-positive Malignant Lymphomas: a Prospective, International, Multi-center, Comparative, Randomized, Cross-over, Open-label Lymphoma Diagnostic Trial
Enrollment Status: Recruiting
Publish Date: February 26, 2025
Intervention Type: Drug
Study Phase: Phase 3

Summary: This will be a pivotal prospective prospective, international, multi-center, comparative, randomized, cross-over, open-label lymphoma diagnostic trial to assess the diagnostic performance and safety of the positron emission tomography (PET) imaging agent \[68Ga\]Ga-PTF) , versus \[18F\]FDG PET/CT imaging, for staging of patients with confirmed marginal zone lymphoma exemplary for CXCR4-positive ma...

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Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)
Enrollment Status: Recruiting
Publish Date: February 24, 2025

Background: The development of new technologies now allow scientists to investigate the molecular basis and clinical manifestations of monoclonal B cell lymphocytosis (MBL), chronic lymphocytic leukemia(CLL)/small lymphocytic lymphoma (SLL), lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM), and splenic marginal zone lymphoma (SMZL). Applying these methods in a natural history study can clar...

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