Maternally Inherited Leigh Syndrome
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Maternally Inherited Leigh Syndrome Overview

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Learn About Maternally Inherited Leigh Syndrome

What is the definition of Maternally Inherited Leigh Syndrome?
Mitochondrial DNA-associated Leigh syndrome is a progressive brain disorder that usually appears in infancy or early childhood. Affected children may experience vomiting, seizures, delayed development, muscle weakness, and problems with movement. Heart disease, kidney problems, and difficulty breathing can also occur in people with this disorder. Mitochondrial DNA-associated Leigh syndrome is a subtype of Leigh syndrome and is caused by changes in mitochondrial DNA. Genetic changes in at least 11 mitochondrial genes have been found to cause mtDNA-associated Leigh syndrome. This condition has an inheritance pattern known as maternal or mitochondrial inheritance. Because mitochondria can be passed from one generation to the next only through egg cells (not through sperm cells), only females pass Mitochondrial DNA-associated Leigh syndrome to their children.
What are the alternative names for Maternally Inherited Leigh Syndrome?
  • Mitochondrial DNA-associated Leigh syndrome
  • Leigh disease, maternally inherited
  • MILS
  • Maternally inherited Leigh syndrome
  • Subacute necrotizing encephalomyelopathy maternally inherited
Who are the top Maternally Inherited Leigh Syndrome Local Doctors?
Advanced in Maternally Inherited Leigh Syndrome
Dr. Sumit Parikh
Pediatric Neurology
Advanced in Maternally Inherited Leigh Syndrome
Dr. Sumit Parikh
Pediatric Neurology
Referral may be required

Cleveland Clinic Main Campus

9500 Euclid Avenue, 
Cleveland, OH 
216-444-2200
Experience:
32+ years
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Sumit Parikh is a Pediatric Neurologist practicing medicine in Cleveland, Ohio. He has been practicing medicine for over 32 years. Dr. Parikh is rated as an Advanced provider by MediFind in the treatment of Maternally Inherited Leigh Syndrome. He is also highly rated in 168 other conditions, according to our data. His clinical expertise encompasses Leigh Syndrome, Maternally Inherited Leigh Syndrome, Kearns-Sayre Syndrome, and MELAS Syndrome. Dr. Parikh is board certified in American Board Of Psychiatry And Neurology, 2006.

Advanced in Maternally Inherited Leigh Syndrome
Dr. Andrew S. Gelfand
Pediatric Pulmonology | Pediatrics
Advanced in Maternally Inherited Leigh Syndrome
Dr. Andrew S. Gelfand
Pediatric Pulmonology | Pediatrics
Referral may be required

UT Southwestern - Pediatrics

5323 Harry Hines Blvd, 
Dallas, TX 
214-456-4597
Languages Spoken:
English, Spanish
See accepted insurances

Andrew Gelfand is a Pediatrics specialist and a Pediatric Pulmonologist practicing medicine in Dallas, Texas. Dr. Gelfand is rated as an Advanced provider by MediFind in the treatment of Maternally Inherited Leigh Syndrome. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Congenital Central Hypoventilation Syndrome, Lung Agenesis, Bronchiolitis Obliterans, and Congenital Unilateral Pulmonary Hypoplasia.

 
 
 
 
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Advanced in Maternally Inherited Leigh Syndrome
Dr. Arjun Seth
Neuromusculoskeletal Medicine
Advanced in Maternally Inherited Leigh Syndrome
Dr. Arjun Seth
Neuromusculoskeletal Medicine
Referral may be required
259 E Erie St Ste 1900, Lavin Family Pavilion, 
Chicago, IL 
312-695-7950
Experience:
10+ years
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Arjun Seth is a Neuromusculoskeletal Medicine provider practicing medicine in Chicago, Illinois. He has been practicing medicine for over 10 years. Dr. Seth is rated as an Advanced provider by MediFind in the treatment of Maternally Inherited Leigh Syndrome. He is also highly rated in 2 other conditions, according to our data. His clinical expertise encompasses Maternally Inherited Leigh Syndrome, Leigh Syndrome, and Foot Drop. Dr. Seth is board certified in American Board Of Psychiatry And Neurology - Neurology (Certified).

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What are the latest Maternally Inherited Leigh Syndrome Clinical Trials?
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Enrollment Status: Recruiting
Publish Date: February 04, 2026

Summary: The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.

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Coordination of Rare Diseases at Sanford
Coordination of Rare Diseases at Sanford
Enrollment Status: Recruiting
Publish Date: May 29, 2025

Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center