Maternally Inherited Leigh Syndrome Overview

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Learn About Maternally Inherited Leigh Syndrome

What is the definition of Maternally Inherited Leigh Syndrome?
Mitochondrial DNA-associated Leigh syndrome is a progressive brain disorder that usually appears in infancy or early childhood. Affected children may experience vomiting, seizures, delayed development, muscle weakness, and problems with movement. Heart disease, kidney problems, and difficulty breathing can also occur in people with this disorder. Mitochondrial DNA-associated Leigh syndrome is a subtype of Leigh syndrome and is caused by changes in mitochondrial DNA. Genetic changes in at least 11 mitochondrial genes have been found to cause mtDNA-associated Leigh syndrome. This condition has an inheritance pattern known as maternal or mitochondrial inheritance. Because mitochondria can be passed from one generation to the next only through egg cells (not through sperm cells), only females pass Mitochondrial DNA-associated Leigh syndrome to their children.
What are the alternative names for Maternally Inherited Leigh Syndrome?
  • Mitochondrial DNA-associated Leigh syndrome
  • Leigh disease, maternally inherited
  • MILS
  • Maternally inherited Leigh syndrome
  • Subacute necrotizing encephalomyelopathy maternally inherited
Who are the top Maternally Inherited Leigh Syndrome Local Doctors?
Sumit Parikh
Advanced in Maternally Inherited Leigh Syndrome
Dr. Sumit Parikh
Pediatric Neurology
Advanced in Maternally Inherited Leigh Syndrome
Dr. Sumit Parikh
Pediatric Neurology

Cleveland Clinic Main Campus

9500 Euclid Avenue, 
Cleveland, OH 
216-444-2200
Experience:
32+ years
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Sumit Parikh is a Pediatric Neurologist in Cleveland, Ohio. Dr. Parikh has been practicing medicine for over 32 years and is rated as an Advanced provider by MediFind in the treatment of Maternally Inherited Leigh Syndrome. His top areas of expertise are Kearns-Sayre Syndrome, Maternally Inherited Leigh Syndrome, Leigh Syndrome, and MELAS Syndrome.

Arjun Seth
Advanced in Maternally Inherited Leigh Syndrome
Dr. Arjun Seth
Neuromusculoskeletal Medicine
Advanced in Maternally Inherited Leigh Syndrome
Dr. Arjun Seth
Neuromusculoskeletal Medicine
259 E Erie St Ste 1900, Lavin Family Pavilion, 
Chicago, IL 
312-695-7950
Experience:
10+ years
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Arjun Seth is a Neuromusculoskeletal Medicine provider in Chicago, Illinois. Dr. Seth has been practicing medicine for over 10 years and is rated as an Advanced provider by MediFind in the treatment of Maternally Inherited Leigh Syndrome. His top areas of expertise are Leigh Syndrome, Maternally Inherited Leigh Syndrome, and Foot Drop.

 
 
 
 
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Distinguished in Maternally Inherited Leigh Syndrome
Ji-hoon U. Na
Distinguished in Maternally Inherited Leigh Syndrome
Ji-hoon U. Na
Seoul, KR 

Ji-hoon Na practices in Seoul, Republic of Korea. Mr. Na is rated as a Distinguished expert by MediFind in the treatment of Maternally Inherited Leigh Syndrome. His top areas of expertise are Maternally Inherited Leigh Syndrome, Leigh Syndrome, Lennox-Gastaut Syndrome (LGS), and MELAS Syndrome.

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What are the latest Maternally Inherited Leigh Syndrome Clinical Trials?
Coordination of Rare Diseases at Sanford
Coordination of Rare Diseases at Sanford
Enrollment Status: Recruiting
Publish Date: May 29, 2025

Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center