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Condition

Maturity Onset Diabetes of the Young

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Condition 101

What is the definition of Maturity Onset Diabetes of the Young?

Maturity-onset diabetes of the young (MODY) is a form of diabetes that is characterized by an early onset diabetes.  MODY represents about 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. It is due to a primary defect in pancreatic β-cell function. There are several MODY subtypes with distinct genetic causes: MODY1, caused by mutations in the HNF4A gene; MODY2, caused by mutations in GCK gene; MODY3 caused by mutations in the HNFA1 (the most common type); MODY4 caused by mutations in the PDX1 gene; MODY5 caused by mutations in the HNF1B gene; MODY6 caused by mutations in the NEUROD1 gene; MODY7 caused by mutations in the KLF11 gene; MODY8 caused by mutations in the CEL gene; MODY9 caused by mutations in the PAX4 gene; MODY10 caused by mutations in the INS gene; MODY11 caused by mutations in the BLK gene; MODY12 caused by mutations in the ABCC8 gene; MODY13  caused by heterozygous mutation in the KCNJ11 gene; and MODY14 caused by mutations in the APPL1 gene. It is inherited in an autosomal dominant pattern. Treatment depends on the subtype and may include sulfonylureas, insulin or diet and exercise.

What are the alternative names for Maturity Onset Diabetes of the Young?

  • MODY
  • Mason type diabetes

Top Global Doctors

MV
Elite
Martine Vaxillaire
Lille, 32, FR
Sian L. Ellard
SE
Elite
Sian L. Ellard
Exeter, ENG, GB
PN
Elite
Pal R. Njolstad
Bergen, 12, NO

Latest Research

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Clinical Trials

Clinical Trial
Other
  • Status: Recruiting
  • Participants: 916
  • Start Date: October 2013
A Cross-sectional Study of Young-onset Diabetes in Two UK Ethnic Groups.