Mayer-Rokitansky-Kuster-Hauser Syndrome Overview
Learn About Mayer-Rokitansky-Kuster-Hauser Syndrome
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that causes the vagina and uterus to be underdeveloped or absent. Without a uterus, affected women do not have menstrual periods. Often, the first noticeable sign of MRKH syndrome is that menstruation does not begin by age 15 (primary amenorrhea).
The cause of MRKH syndrome is unknown. Changes in several genes that are involved in development before birth have been identified in girls and women with MRKH syndrome. However, these genetic changes have been found in only a small number of affected people, and it is unclear whether they actually cause MRKH syndrome. Researchers are working to determine how genetic changes could lead to problems with the development of the female reproductive system.
MRKH syndrome affects approximately 1 in 4,500 female newborns.
Most cases of MRKH syndrome occur in girls and women with no history of the disorder in their family.
Sara Brucker practices in Tuebingen, Germany. Brucker and is rated as an Elite expert by MediFind in the treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome. Her top areas of expertise are Mayer-Rokitansky-Kuster-Hauser Syndrome, Mullerian Aplasia, Kuster Syndrome, Hysterectomy, and Endoscopy.
Kristin Rall practices in Tuebingen, Germany. Rall and is rated as an Elite expert by MediFind in the treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome. Her top areas of expertise are Mayer-Rokitansky-Kuster-Hauser Syndrome, Mullerian Aplasia, Kuster Syndrome, Reconstructive Urology Surgery, and Endoscopy.
Lan Zhu practices in Beijing, China. Zhu and is rated as an Elite expert by MediFind in the treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome. Their top areas of expertise are Mayer-Rokitansky-Kuster-Hauser Syndrome, Uterine Prolapse, Mullerian Aplasia, Hysterectomy, and Endoscopy.
Summary: Uterus transplantation (UTx) is the only causative treatment for congenital or acquired uterus absence. Individual cases of UTx from a live donor (LD UTx) with healthy child birth performed so far showed favourable outcomes. The present study will include both LD UTx and UTx from deceased donors after brain death (DBD UTx). The aim is treatment of uterine infertility by UTx. It is is an ethically ...
Published Date: April 04, 2025
Published By: National Institutes of Health