Learn About Mcleod Neuroacanthocytosis Syndrome

What is the definition of Mcleod Neuroacanthocytosis Syndrome?

McLeod neuroacanthocytosis syndrome is primarily a neurological disorder that occurs almost exclusively in boys and men. This disorder affects movement in many parts of the body. People with McLeod neuroacanthocytosis syndrome also have abnormal star-shaped red blood cells (acanthocytosis). This condition is one of a group of disorders called neuroacanthocytoses that involve neurological problems and abnormal red blood cells.

Save information for later
Sign Up
What are the causes of Mcleod Neuroacanthocytosis Syndrome?

Mutations in the XK gene cause McLeod neuroacanthocytosis syndrome. The XK gene provides instructions for producing the XK protein, which carries the blood antigen Kx. Blood antigens are found on the surface of red blood cells and determine blood type. The XK protein is found in various tissues, particularly the brain, muscle, and heart. The function of the XK protein is unclear; researchers believe that it might play a role in transporting substances into and out of cells. On red blood cells, the XK protein attaches to another blood group protein, the Kell protein. The function of this blood group complex is unknown.

How prevalent is Mcleod Neuroacanthocytosis Syndrome?

McLeod neuroacanthocytosis syndrome is rare; approximately 150 cases have been reported worldwide.

Is Mcleod Neuroacanthocytosis Syndrome an inherited disorder?

McLeod neuroacanthocytosis syndrome is inherited in an X-linked recessive pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation must be present in both copies of the gene to cause the disorder. Males are affected by X-linked recessive disorders much more frequently than females. Rarely, females with a mutation in one copy of the XK gene can have the characteristic misshapen blood cells and movement problems associated with McLeod neuroacanthocytosis syndrome. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

Who are the top Mcleod Neuroacanthocytosis Syndrome Local Doctors?
Learn about our expert tiers
Learn more
What are the latest Mcleod Neuroacanthocytosis Syndrome Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: April 01, 2015Published By: National Institutes of Health

What are the Latest Advances for Mcleod Neuroacanthocytosis Syndrome?
Chronic granulomatous disease and McLeod syndrome: Stem cell transplant and transfusion support in a 2-year-old patient-a case report.
McLeod Syndrome in a Commercial Airline Pilot.
Tired of the same old research?
Check Latest Advances