Learn About Medullary Thyroid Carcinoma
Medullary carcinoma of the thyroid is cancer of the thyroid gland that starts in cells that release a hormone called calcitonin. These cells are called "C" cells. The thyroid gland is located inside the front of your lower neck.
Thyroid - medullary carcinoma; Cancer - thyroid (medullary carcinoma); MTC; Thyroid nodule - medullary
The cause of medullary carcinoma of the thyroid (MTC) is unknown. MTC is very rare. It can occur in children and adults.
Unlike other types of thyroid cancer, MTC is less likely to be caused by radiation therapy to the neck given to treat other cancers during childhood.
There are two forms of MTC:
- Sporadic MTC, which does not run in families. Most MTCs are sporadic. This form mainly affects older adults.
- Hereditary MTC, which runs in families.
You have an increased risk for this type of cancer if you have:
- A family history of MTC
- A family history of multiple endocrine neoplasia (MEN)
- A prior history of pheochromocytoma, mucosal neuromas, hyperparathyroidism or pancreatic endocrine tumors
Other types of thyroid cancer include:
- Anaplastic carcinoma of the thyroid
- Follicular carcinoma of the thyroid
- Papillary carcinoma of the thyroid
- Thyroid lymphoma
MTC often begins as a small lump (nodule) in the thyroid gland. There also may be lymph node swelling in the neck. As a result, symptoms may include:
- Swelling of the neck
- Hoarseness
- Breathing problems due to narrowing of airways
- Cough
- Cough with blood
- Diarrhea due to high calcitonin level
Treatment involves surgery to remove the thyroid gland and surrounding lymph nodes. Because this is an uncommon tumor, surgery should be performed by a surgeon who is familiar with this type of cancer and experienced with the operation required.
Further treatment will depend on your calcitonin levels. A rise in calcitonin levels again may indicate new growth of the cancer.
- Chemotherapy and radiation do not work very well for this type of cancer.
- Radiation is used in some people after surgery.
- Newer targeted therapies may reduce tumor growth also. Your provider can tell you more about these, if needed.
Near relatives of persons diagnosed with hereditary forms of MTC are at increased risk of this cancer and should discuss with their providers.
Mskcc Surgery Group
Ian Ganly is an Otolaryngologist in New York, New York. Dr. Ganly is rated as an Elite provider by MediFind in the treatment of Medullary Thyroid Carcinoma. His top areas of expertise are Thyroid Cancer, Papillary Thyroid Cancer, Tongue Cancer, Thyroidectomy, and Laryngectomy.
MD Anderson
Mark Zafereo is an Otolaryngologist in Houston, Texas. Dr. Zafereo is rated as an Elite provider by MediFind in the treatment of Medullary Thyroid Carcinoma. His top areas of expertise are Anaplastic Thyroid Cancer, Thyroid Cancer, Papillary Thyroid Cancer, Thyroidectomy, and Laryngectomy.
Massachusetts General Physicians Organization Inc
Lori Wirth is an Oncologist in Boston, Massachusetts. Dr. Wirth is rated as an Elite provider by MediFind in the treatment of Medullary Thyroid Carcinoma. Her top areas of expertise are Thyroid Cancer, Medullary Thyroid Carcinoma, Papillary Thyroid Cancer, Tissue Biopsy, and Thyroidectomy. Dr. Wirth is currently accepting new patients.
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Most people with MTC live at least 5 years after diagnosis, depending upon the stage of the cancer. The 10-year survival rate is 65%.
Complications may include:
- Cancer spreads to other areas of the body
- Parathyroid glands are accidentally removed during surgery
Contact your provider if you have symptoms of MTC.
Prevention may not be possible. But, being aware of your risk factors, especially your family history, may allow for early diagnosis and treatment. For people who have a very strong family history of MTC, the option to remove the thyroid gland may be recommended. You should carefully discuss this option with a doctor who is very familiar with the disease.
Background: \- Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. These problems include adrenal gland tumors, hormone changes, and problems with the bones and other organs. Not much is k...
Summary: This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understanding disease management. The goal of this study is to learn about how medullary thyroid cancer develops and progresses.
Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Kim M, Kim BH. Current guidelines for management of medullary thyroid carcinoma. Endocrinol Metab. 2021;36(3):514-524. PMID: 34154310 pubmed.ncbi.nlm.nih.gov/34154310/.
National Cancer Institute website. Thyroid cancer treatment (PDQ) - health professional version. www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq. Updated April 11, 2024. Accessed May 3, 2024.
Pearce EN, Hollenberg AN. Thyroid. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 207.
Suh I, Sosa JA. Thyroid. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. St Louis, MO: Elsevier; 2022:chap 37.