Condition 101 About Medulloblastoma

What is the definition of Medulloblastoma?

Medulloblastoma is a type of brain tumor that occurs in the cerebellum. The cerebellum is important for coordination, particularly balance and movement. Medulloblastoma often spreads through cerebrospinal fluid (CSF) to other areas of the brain and the spinal cord. Medulloblastoma is the most common childhood malignant brain tumor. Roughly 250-500 new cases of medulloblastoma are diagnosed each year. 

What are the causes for Medulloblastoma?

The cause of medulloblastomas is still unknown. However, medulloblastomas generally tend to be more common in children than adults. Males are also more likely to develop medulloblastomas than females.

What are the symptoms for Medulloblastoma?

Common symptoms of medulloblastoma include headaches, nausea, vomiting, fatigue, poor coordination, dizziness, or difficulty walking. If the medulloblastoma has spread to the spinal cord, symptoms may also include back pain and difficulty controlling bowel and bladder functions. 

Advocacy Organizations

Keep Punching, Inc., supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.

What are the current treatments for Medulloblastoma?

Treatment for glioma may include surgery, radiation therapy, and/or chemotherapy. Surgery to remove as much of the tumor as possible is generally the first step in treating medulloblastoma. However, if a tumor is located near a sensitive area in the brain, surgery may not be possible at all. Radiation therapy often follows surgery for the treatment of medulloblastoma. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Chemotherapy involves the use of drugs, either taken orally or injected through a vein, to kill tumor cells. Chemotherapy is often used in combination with radiation therapy.

How do I prevent Medulloblastoma?

There is no known way to prevent medulloblastomas. However, if you develop any symptoms common to a medulloblastoma, it is recommended to make an appointment with your doctor to be properly diagnosed.

Clinical Trials For Medulloblastoma

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 1/Phase 2
  • Intervention Type: Biological
  • Participants: 228
  • Start Date: April 15, 2021
Phase 1/2 Study of Bempegaldesleukin in Combination With Nivolumab in Children, Adolescents, and Young Adults With Recurrent or Refractory Malignancies (PIVOT IO 020)
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 62
  • Start Date: April 2, 2021
Phase 2 Study of Intraventricular Omburtamab-based Radioimmunotherapy for Pediatric Patients With Recurrent Medulloblastoma and Ependymoma