Learn About Melanoma of the Eye
Melanoma of the eye is cancer that occurs in various parts of the eye.
Malignant melanoma - choroid; Malignant melanoma - eye; Eye tumor; Ocular melanoma
Melanoma is a very aggressive type of cancer that can spread rapidly. It usually is a type of skin cancer.
Melanoma of the eye can affect several parts of the eye, including the:
- Choroid
- Ciliary body
- Conjunctiva
- Eyelid
- Iris
- Orbit
The choroid layer is the most likely site of melanoma in the eye. This is the layer of blood vessels and connective tissue between the white of the eye and retina (back of the eye).
The cancer may only be in the eye. Or, it may spread (metastasize) to another location in the body, most commonly the liver. Melanoma can also begin on the skin or other organs in the body and spread to the eye.
Melanoma is the most common type of eye tumor in adults. Even so, melanoma that starts in the eye is rare.
Too much exposure to sunlight is an important risk factor for melanoma. People who have fair skin and blue eyes are most affected.
Symptoms of melanoma of the eye may include any of the following:
- Bulging eyes
- Change in iris color
- Poor vision in one eye
- Red, painful eye
- Small defect on the iris or conjunctiva
In some cases, there may be no symptoms.
Small melanomas may be treated with:
- Surgery
- Laser
- Radiation therapy (such as Gamma Knife, CyberKnife, brachytherapy)
Surgery to remove the eye (enucleation) may be needed.
Other treatments that may be used include:
- Chemotherapy, if the cancer has spread beyond the eye
- Immunotherapy, which uses medicines to help your immune system fight the melanoma
Jules Stein Eye Institute Medical Group
Tara Mccannel is an Ophthalmologist in Arcadia, California. Dr. Mccannel is rated as an Elite provider by MediFind in the treatment of Melanoma of the Eye. Her top areas of expertise are Melanoma of the Eye, Uveal Melanoma, Metastatic Uveal Melanoma, Vitrectomy, and Cataract Removal.
Stanford Health Care
Prithvi Mruthyunjaya is an Ophthalmologist in Stanford, California. Dr. Mruthyunjaya is rated as an Elite provider by MediFind in the treatment of Melanoma of the Eye. His top areas of expertise are Melanoma of the Eye, Uveal Melanoma, Retinal Detachment, Vitrectomy, and Trabeculectomy.
Trustees Of Columbia University In The City Of New York
Brian Marr is an Ophthalmologist in New York, New York. Dr. Marr is rated as an Elite provider by MediFind in the treatment of Melanoma of the Eye. His top areas of expertise are Retinoblastoma, Melanoma of the Eye, Metastatic Uveal Melanoma, Uveal Melanoma, and Vitrectomy.
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
The outcome for melanoma of the eye depends on the size of the cancer when it is diagnosed. Most people survive at least 5 years from the time of diagnosis if the cancer has not spread outside the eye.
If the cancer has spread outside the eye, the chance of long-term survival is much lower.
Problems that may develop due to melanoma of the eye include:
- Distortion or loss of vision
- Retinal detachment
- Spread of the tumor to other areas of the body
Contact your health care provider for an appointment if you have symptoms of melanoma of the eye.
The most important way to prevent melanoma of the eye is to protect the eyes from sunlight, especially between 10 a.m. and 4 p.m., when the sun's rays are most intense. Wear sunglasses that have ultraviolet protection.
A yearly eye exam is recommended.
Summary: Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma
Summary: This is a prospective phase II multi-center trial of the combination of the PARP inhibitor olaparib with the immune checkpoint inhibitor pembrolizumab in advanced uveal melanoma.
Published Date: August 28, 2023
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Dalvin LA, Shields CL. Tumors of the uvea. In: Yanoff M, Duker JS, eds. Ophthalmology. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 8.2.
McCannel TA. Epidemiology of posterior uveal melanoma. In: Sadda SVR, Sarraf D, Freund KB, et al, eds. Ryan's Retina. 7th ed. Philadelphia, PA: Elsevier; 2023:chap 140.
National Cancer Institute website. Intraocular (uveal) melanoma treatment (PDQ) -- health professional version. www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq. Updated May 12, 2023. Accessed September 12, 2023.
Shields CL, Shields JA. Overview of management of posterior uveal melanoma. In: Sadda SVR, Sarraf D, Freund KB, et al, eds. Ryan's Retina. 7th ed. Philadelphia, PA: Elsevier; 2023:chap 144.