Molecular Analysis of Childhood and Adolescent Melanocytic Lesions
This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions. PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi). SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.
• Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:
‣ Conventional or adult-type melanoma
⁃ Spitzoid melanoma/atypical Spitz tumor
⁃ Congenital melanoma
⁃ Melanoma arising in a giant congenital nevus
⁃ Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
• Participant was \<19 years of age at the time of diagnosis.
• Tissue is available for biologic studies.
• Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials.