Learn About Merkel Cell Carcinoma

What is the definition of Merkel Cell Carcinoma?
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. It usually develops as a single, painless, bump on sun-exposed skin. The bump may be skin-colored or red-violet, and tends to grow rapidly over weeks to months. It may spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body. Factors associated with developing MCC include increasing age, fair skin, a history of extensive sun exposure, chronic immune suppression, and the Merkel cell polyomavirus. The Merkel cell polyomavirus has been detected in most people who have MCC.
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What are the alternative names for Merkel Cell Carcinoma?
  • Merkel cell carcinoma
  • Carcinoma, merkel cell
  • Cutaneous neuroendocrine carcinoma
  • Merkel cell cancer
  • Merkle tumors
Who are the top Merkel Cell Carcinoma Local Doctors?
SD
Sandra P. Dangelo
Dr. Sandra P. Dangelo
Oncology
Elite
Highly rated in
35
conditions
Oncology

Memorial Sloan Kettering Cancer Center

1275 York Ave, 
New York, NY 

Sandra Dangelo is an Oncologist in New York, New York. Dangelo has been practicing medicine for over 19 years and is rated as an Elite expert by MediFind in the treatment of Merkel Cell Carcinoma. She is also highly rated in 35 other conditions, according to our data. Her top areas of expertise are Adult Soft Tissue Sarcoma, Liposarcoma, Merkel Cell Carcinoma, Synovial Sarcoma, and Liver Embolization. She is licensed to treat patients in New York. Dangelo is currently accepting new patients.

GR
Guilherme Rabinowits
Dr. Guilherme Rabinowits
Hematology Oncology | Oncology
Elite
Highly rated in
15
conditions
Hematology Oncology
Oncology

Baptist Health South Florida

Baptist Hospital

8900 N Kendall Dr, 
Miami, FL 

Guilherme Rabinowits is a Hematologist Oncology specialist and an Oncologist in Miami, Florida. Rabinowits has been practicing medicine for over 23 years and is rated as an Elite expert by MediFind in the treatment of Merkel Cell Carcinoma. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Merkel Cell Carcinoma, Head and Neck Squamous Cell Carcinoma (HNSCC), Tongue Cancer, and Squamous Cell Skin Carcinoma. He is licensed to treat patients in Florida. Rabinowits is currently accepting new patients.

 
 
 
 
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VS
Vernon K. Sondak
Dr. Vernon K. Sondak
General Surgery
Elite
Highly rated in
6
conditions
General Surgery

Moffitt Cancer Center

Moffitt Cancer Center, Richard M. Schulze Family Foundation Outpatient Center At McKinley Campus

10920 Mckinley Dr, 
Tampa, FL 

Vernon Sondak is a General Surgeon in Tampa, Florida. Sondak has been practicing medicine for over 43 years and is rated as an Elite expert by MediFind in the treatment of Merkel Cell Carcinoma. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Melanoma, Merkel Cell Carcinoma, Neuroendocrine Tumor, and Lymphofollicular Hyperplasia. He is licensed to treat patients in Florida. Sondak is currently accepting new patients.

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What are the latest Merkel Cell Carcinoma Clinical Trials?
A First-in-Human, Phase 1/2, Dose Escalation Study of BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors
Enrollment Status: Recruiting
Publish Date: December 15, 2022
Intervention Type: Biological
Study Phase: Phase 1/Phase 2

Summary: This is a first-in-human (FIH), Phase 1, open-label, multicenter study to assess safety and determine the recommended Phase 2 dose (RP2D) of BOXR1030 administration after lymphodepleting chemotherapy (LD chemotherapy) in subjects with glypican-3 positive (GPC3+) advanced solid tumors.

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A Phase II, Single-Arm Open-Label Study of the Combination of Atezolizumab and Bevacizumab in Rare Solid Tumors
Who is this study for: Adult patients with squamous cell carcinomas and rare solid tumors
Enrollment Status: Active, not recruiting
Publish Date: December 08, 2022
Intervention Type: Other, Biological, Drug
Study Drugs: AtezolizumabBevacizumab
Study Phase: Phase 2

Summary: This phase II trial studies how well atezolizumab and bevacizumab work in treating patients with rare solid tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab and bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Merkel Cell Carcinoma?
Ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma: a multicenter study of the prospective skin cancer registry ADOREG.
Condition: Merkel Cell Carcinoma
Journal: Journal for immunotherapy of cancer
Treatment Used: Ipilimumab Plus Nivolumab
Number of Patients: 14
Published: November 30, 2022
Does Preventive Negative Pressure Wound Therapy (NPWT) reduce local complications following Lymph Node Dissection (LND) in the management of metastatic skin tumors?
Condition: Metastatic Skin Tumors
Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Treatment Used: Negative Pressure Wound Therapy (NPWT)
Number of Patients: 0
Published: October 25, 2022
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Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Condition: Advanced Merkel Cell Carcinoma
Journal: Lancet (London, England)
Treatment Used: Combined Nivolumab and Ipilimumab
Number of Patients: 50
Published: September 15, 2022
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