Learn About Metachondromatosis

What is the definition of Metachondromatosis?
Metachondromatosis (MC) is a rare bone disorder characterized by the presence of both multiple enchondromas and osteochondroma-like lesions. The first signs occur during the first decade of life. Osteochondromas most commonly occur in the hands and feet (predominantly in digits and toes), and enchondromas involve the iliac crests and metaphyses of long bones. The lesions typically spontaneously decrease in size or regress. Nerve paralysis or vascular complications may occur in some cases. The condition has been linked to mutations in the PTPN11 gene in several families and is inherited in an autosomal dominant manner. Treatment may include surgery to remove osteochondromas in severe cases.
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What are the alternative names for Metachondromatosis?
  • METCDS
What are the symptoms of Metachondromatosis?
Metachondromatosis (MC) is characterized by the presence of both multiple enchondromas and osteochondromas. The features of the condition generally become apparent in the first decade of life. Enchondromas are benign (noncancerous) tumors that appear on the inside of the bone. Those that are associated MC typically involve the iliac crests (part of the pelvis) and metaphyses of long bones, particularly the proximal femur (portion of the thigh bone closer to the trunk). These tumors are usually painless, but when they appear in the hands or feet, or in multiple lesions (as is typical in MC), they can deform the bone.Osteochondromas are also benign tumors. These form on the surface of the bone near the growth plates (areas of developing cartilage tissue near the ends of long bones in children) and are made up of both bone and cartilage. Osteochondromas may grow as the affected child grows, and stop growing when the child reaches skeletal maturity. They have a tendency to regress or disappear after the first or second decade of life. Those that are associated with MC most frequently occur in the small bones of the hands and feet, predominantly in digits and toes. The characteristic location and orientation of these in individuals with MC (as well as lack of bone shortening and short stature) are what generally differentiate MC from hereditary multiple osteochondromas (HMO), a disorder with overlapping features. The osteochondromas of MC point toward the joint to which they are adjacent (whereas those of HMO point away). Osteochondromas often cause painless bumps, but pain or other discomfort may occur if the tumors put pressure on soft tissues, nerves, or blood vessels.
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Who are the top Metachondromatosis Local Doctors?
Distinguished
Highly rated in
27
conditions
Orthopedics

Johns Hopkins Outpatient Center

Baltimore, MD 

Adam Levin is an Orthopedics doctor in Baltimore, Maryland. Dr. Levin has been practicing medicine for over 17 years and is rated as a Distinguished doctor by MediFind in the treatment of Metachondromatosis. He is also highly rated in 27 other conditions, according to our data. His top areas of expertise are Adult Soft Tissue Sarcoma, Ollier Disease, Maffucci Syndrome, and Bone Tumor. He is board certified in Orthopedic Surgery and licensed to treat patients in New York. Dr. Levin is currently accepting new patients.

Distinguished
Highly rated in
52
conditions
Orthopedics

Indian Creek Campus Medical Office Building

Overland Park, KS 

Howard Rosenthal is an Orthopedics doctor in Overland Park, Kansas. Dr. Rosenthal has been practicing medicine for over 37 years and is rated as a Distinguished doctor by MediFind in the treatment of Metachondromatosis. He is also highly rated in 52 other conditions, according to our data. His top areas of expertise are Osteochondroma, Adult Soft Tissue Sarcoma, Bone Tumor, and Epithelioid Sarcoma. He is board certified in Orthopedic Surgery and licensed to treat patients in Kansas. Dr. Rosenthal is currently accepting new patients.

 
 
 
 
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Distinguished
Highly rated in
5
conditions
Occupational Medicine

Texas Scottish Rite Hospital For Children

Roslyn, NY 

Harry Kim is an Occupational Medicine doctor in Roslyn, New York. Dr. Kim is rated as a Distinguished doctor by MediFind in the treatment of Metachondromatosis. He is also highly rated in 5 other conditions, according to our data. His top areas of expertise are Legg-Calve-Perthes Disease, Osteonecrosis, Metachondromatosis, and Necrosis. He is licensed to treat patients in New York.

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What are the Latest Advances for Metachondromatosis?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.