Learn About Mikulicz Disease

What is the definition of Mikulicz Disease?
IgG4-related dacryoadenitis and sialoadenitis (formerly called Mikulicz disease) is an IgG4-related disease characterized by inflammation of the lacrimal glands (which produce tears), parotid glands, and submandibular glands (two of the major salivary glands). In some cases, it also affects other glands or organs. The condition is usually painless, mainly causing mouth and eye dryness, and swelling over the affected glands. When other organs are affected, it can be accompanied by complications such as autoimmune pancreatitis, retroperitoneal fibrosis, and tubulointerstitial nephritis. The underlying cause of IgG4-related disease is still not known.
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What are the alternative names for Mikulicz Disease?
  • IgG4-related dacryoadenitis and sialadenitis
  • Chronic dacryoadenitis and sialadenitis
  • Mikulicz disease (former)
  • Mikulicz syndrome (former)
  • Mikulicz's disease (former)
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Mikulicz Disease?
A Case of IgG4-Related Disease Arising in Female Periurethra.
Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases.
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