Learn About Mitochondrial Trifunctional Protein Deficiency

What is the definition of Mitochondrial Trifunctional Protein Deficiency?

Mitochondrial trifunctional protein deficiency is a rare condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting).

Save information for later
Sign Up
What are the causes of Mitochondrial Trifunctional Protein Deficiency?

Mutations in the HADHA and HADHB genes cause mitochondrial trifunctional protein deficiency. These genes each provide instructions for making part of an enzyme complex called mitochondrial trifunctional protein. This enzyme complex functions in mitochondria, the energy-producing centers within cells. As the name suggests, mitochondrial trifunctional protein contains three enzymes that each perform a different function. This enzyme complex is required to break down (metabolize) a group of fats called long-chain fatty acids. Long-chain fatty acids are found in foods such as milk and certain oils. These fatty acids are stored in the body's fat tissues. Fatty acids are a major source of energy for the heart and muscles. During periods of fasting, fatty acids are also an important energy source for the liver and other tissues.

How prevalent is Mitochondrial Trifunctional Protein Deficiency?

Mitochondrial trifunctional protein deficiency is a rare disorder; its incidence is unknown.

Is Mitochondrial Trifunctional Protein Deficiency an inherited disorder?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Mitochondrial Trifunctional Protein Deficiency Local Doctors?
Learn about our expert tiers
Learn more
What are the latest Mitochondrial Trifunctional Protein Deficiency Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: September 01, 2019Published By: National Institutes of Health

What are the Latest Advances for Mitochondrial Trifunctional Protein Deficiency?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.