Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse: the SCIMITAR Trial
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This is a multicenter, observational prospective and retrospective study which aims are: 1) to compute a scoring model potentially predictive for the diagnosis of fibrosis by CMR in patients with MVP; 2) to identify specific features that may predispose to ≥ mild VAs or SCD in patients with MVP.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• age ≥ 18 years
• Echocardiographic diagnosis of mitral valve prolaspe, defined as a systolic displacement of one or both mitral leaflets ≥ 2 mm above the plane of the mitral valve annulus in long-axis views
Locations
Other Locations
Italy
Centro Cardiologico Monzino
RECRUITING
Milan
Contact Information
Primary
Gianluca Pontone, MD
gianluca.pontone@cardiologicomonzino.it
0258002574
Time Frame
Start Date: 2023-06-19
Estimated Completion Date: 2026-06-19
Participants
Target number of participants: 300
Treatments
Prospective Cohort
Prospectively enrolled patients will undergo a complete assessment, as clinically indicated, including clinical evaluation, TTE, rest ECG, 24h ECG-monitoring, and CMR. CMR will be performed no more than 6 months apart from other examinations (TTE, rest ECG, 24h ECG-monitoring).
Retrospective Cohort
Patients will be enrolled retrospectively, in case they have already performed all examinations between 2016 and 2023
Related Therapeutic Areas
Sponsors
Collaborators: IRCCS Ospedale San Raffaele, Azienda Ulss 2 Marca Trevigiana, Humanitas Hospital, Italy
Leads: Centro Cardiologico Monzino