Choice of Optimal Transcatheter Treatment for Mitral Insufficiency Registry
Status: Recruiting
Location: See all (43) locations...
Study Type: Observational
SUMMARY
This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice. Patients evaluated for TMVR but not undergoing the procedure are no longer systematically included. Historical data may include such patients who subsequently underwent alternative treatments, including transcatheter edge-to-edge repair, mitral valve surgery, or medical/conservative therapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• clinically significant mitral insufficiency
• patient underwent screening for TMVI
• echocardiography data at baseline (and after TMVI, E2E and surgery)
• follow-up of at least 30 days
Locations
United States
Arizona
Tucson Medical Center
RECRUITING
Tucson
California
Cedars-Sinai Medical Center, Los Angeles
RECRUITING
Los Angeles
Florida
Tampa General Hospital
RECRUITING
Tampa
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Minnesota
Minneapolis Heart Institute at Abbott Northwestern Hospital
RECRUITING
Minneapolis
New Jersey
Morristown Medical Center
RECRUITING
Morristown
New York
Montefiore Medical Center
RECRUITING
New York
Oklahoma
Oklahoma Heart Hospital
RECRUITING
Oklahoma City
Texas
Houston Methodist Hospital
RECRUITING
Houston
Other Locations
Australia
St Vincent's Hospital
RECRUITING
Sydney
Austria
Medical University of Vienna
RECRUITING
Vienna
Canada
Québec Heart and Lung Institute (Laval University)
RECRUITING
Québec
Toronto Heart Center
RECRUITING
Toronto
St. Paul's Hospital
RECRUITING
Vancouver
Denmark
Rigshospitalet
RECRUITING
Copenhagen
France
CHU Bordeaux
RECRUITING
Bourdeaux
Lille University Hospital
RECRUITING
Lille
Civils Hospices of Lyon
RECRUITING
Lyon
Clinique Pasteur
RECRUITING
Toulouse
Germany
HDZ Bad Oeynhausen
RECRUITING
Bad Oeynhausen
German Heart Center Berlin
RECRUITING
Berlin
Heart Center Bonn
RECRUITING
Bonn
University Hospital of Cologne
RECRUITING
Cologne
Goethe-Universität - University Hospital Frankfurt
RECRUITING
Frankfurt
University Heart and Vascular Center Hamburg
RECRUITING
Hamburg
University Heart Center Lübeck
RECRUITING
Lübeck
Heart Center of the University Medical Center Mainz
RECRUITING
Mainz
German Heart Centre Munich
RECRUITING
Munich
LMU Munich
RECRUITING
Munich
University Medical Center Ulm
RECRUITING
Ulm
Greece
Interbalkan Medical Center
RECRUITING
Thessaloniki
Italy
ASST Spedali Civili di Brescia
RECRUITING
Brescia
IRCCS Humanitas Research Hospital
RECRUITING
Milan
IRCCS Policlinico San Donato
RECRUITING
Milan
San Raffaele University Hospital
RECRUITING
Milan
University Hospital of Pisa
RECRUITING
Pisa
Norway
Rikshospitalet, Oslo University Hospital (OUS)
RECRUITING
Oslo
Poland
Poznan University of Medical Sciences
RECRUITING
Poznan
Warsaw Medicover Hospital
RECRUITING
Warsaw
Switzerland
Inselspital Bern
RECRUITING
Bern
USZ Zurich
RECRUITING
Zurich
United Kingdom
Royal Brompton Hospital
RECRUITING
London
St Thomas' Hospital - London
RECRUITING
London
Contact Information
Primary
Sebastian Ludwig, MD
se.ludwig@uke.de
+494074100
Backup
Lena Strotmann, MD
L.Strotmann@uke.de
+4074100
Time Frame
Start Date: 2020-11-01
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 1000
Treatments
Transcatheter Mitral Valve Replacement (TMVR)
Patients with successful TMVR screening, who underwent Transcatheter Mitral Valve Replacement subsequently. All devices may be included.
Mitral transcatheter edge-to-edge repair (M-TEER)
Patients with TMVR screening failure, who subsequently underwent interventional mitral valve edge-to-edge repair. Update: These patients are currently no longer systematically included.
Mitral valve surgery (Surgery)
Patients with TMVR screening failure, who subsequently underwent mitral valve surgery (i.e., mitral valve repair or replacement). Update: These patients are currently no longer systematically included.
Medical/conservative therapy
Patients with TMVR screening failure, who subsequently underwent conservative or optimal medical therapy. Update: These patients are currently no longer systematically included.
Authors
Related Therapeutic Areas
Sponsors
Leads: Universitätsklinikum Hamburg-Eppendorf
Collaborators: University Hospital, Bordeaux, Montreal Heart Institute